Li Rui Feng, Wang Liang Fen, Zhang Hai Ying, He Meng Jie
Department of Clinical Pharmacy, Sichuan Provincial Women's and Children's Hospital/The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, People's Republic of China.
Department of Pharmacy, 363 hospital, Chengdu, People's Republic of China.
Drug Healthc Patient Saf. 2025 Jan 6;17:1-6. doi: 10.2147/DHPS.S491648. eCollection 2025.
Niclofolan is a commonly used veterinary drug worldwide. We reported a case of acute niclofolan intoxication in a pregnant woman. We recorded in detail her toxic symptoms, including nausea, vomiting, asthenia, blurred vision, and aberrant blood values. Notably stillbirth was recorded for the first time as indicating its human reproductive toxicity. We also found that an oral therapeutic dosage as described in the literature was likely to lead to stillbirth. Furthermore, we described the treatments received by the patient, including critical care, drug therapy, and plasma exchange, the outcomes of which were excellent. By studying this case, we aimed to enhance recognition and treatment of niclofolan intoxication and to raise concern regarding veterinary drug abuse and exposure risk.
硝氯酚是一种在全球范围内广泛使用的兽药。我们报告了一例孕妇急性硝氯酚中毒病例。我们详细记录了她的中毒症状，包括恶心、呕吐、乏力、视力模糊和异常的血液指标。值得注意的是，首次记录到死产情况，这表明了其对人类的生殖毒性。我们还发现，文献中描述的口服治疗剂量可能会导致死产。此外，我们描述了患者接受的治疗，包括重症监护、药物治疗和血浆置换，治疗效果良好。通过研究该病例，我们旨在提高对硝氯酚中毒的认识和治疗水平，并引起对兽药滥用和暴露风险的关注。
