Yang Yalan, Li Lei
Department of Pathology, West China Second University Hospital, Sichuan University Chengdu, Sichuan, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education Chengdu, Sichuan, China.
Int J Clin Exp Pathol. 2024 Dec 15;17(12):477-486. doi: 10.62347/PTTF8718. eCollection 2024.
Neurotrophic tyrosine kinase receptor (NTRK)-rearranged uterine sarcoma is a rare type of uterine sarcoma. This paper presents a case of a 49-year-old female who was admitted to the hospital due to lower abdominal pain and subsequently diagnosed with tropomyosin 3 (TPM3)::NTRK1-rearranged uterine sarcoma. To our knowledge, TPM3::NTRK1-rearranged sarcomas almost always occur in the cervix, and this is a novel case of uterine corpus occurrence. The patient received chemotherapy and radiotherapy after surgery. No recurrence or metastasis was observed after 9 months of treatment. Moreover, all reported clinicopathological features, treatment methods, and prognoses of NTRK-rearranged uterine sarcoma patients are reviewed herein.
神经营养性酪氨酸激酶受体（NTRK）重排的子宫肉瘤是一种罕见的子宫肉瘤类型。本文报告了一例49岁女性，因下腹部疼痛入院，随后被诊断为原肌球蛋白3（TPM3）::NTRK1重排的子宫肉瘤。据我们所知，TPM3::NTRK1重排的肉瘤几乎总是发生在宫颈，这是一例发生在子宫体的新病例。患者术后接受了化疗和放疗。治疗9个月后未观察到复发或转移。此外，本文还回顾了所有已报道的NTRK重排子宫肉瘤患者的临床病理特征、治疗方法和预后。
