Memon Hamda, Parrondo Ricardo, Schreurs Julianna, Ayala Ernesto, Iqbal Madiha
Department of Family Medicine, Geisinger Health in Wilkes Barre, Wilkes Barre, Pennsylvania, USA.
Division of Hematology and Oncology, Mayo Clinic, Jacksonville, Florida, USA.
J Blood Med. 2025 Jan 6;16:7-13. doi: 10.2147/JBM.S489627. eCollection 2025.
Systemic sclerosis (SSc) is a multi-system disease characterized by a dysregulated immune system. Autologous hematopoietic cell transplantation (AHCT) is the only treatment that has been shown to confer significant benefit in controlling disease and improving survival for patients with SSc. A diagnosis of multiple myeloma (MM) after the diagnosis of SSc is rare and optimal treatment in such cases remains unclear. We here report a case of a female patient who was diagnosed with MM while she was undergoing evaluation for AHCT due to SSc. A novel conditioning regimen for AHCT, with therapeutic efficacy in SSc and MM was offered to the patient, resulting in long term remission of both diseases.
系统性硬化症（SSc）是一种以免疫系统失调为特征的多系统疾病。自体造血细胞移植（AHCT）是唯一已被证明对控制SSc患者的疾病和提高生存率有显著益处的治疗方法。在SSc诊断后再诊断出多发性骨髓瘤（MM）的情况很罕见，此类病例的最佳治疗方法仍不明确。我们在此报告一例女性患者，她因SSc正在接受AHCT评估时被诊断出患有MM。我们为该患者提供了一种新型的AHCT预处理方案，该方案对SSc和MM均有治疗效果，使两种疾病都实现了长期缓解。
