Momeni-Moghaddam Mohammad Amin, Abbasnezhad Abbasali, Ebadi Amir Hossein, Mohebbati Reza
Department of Nutrition and Biochemistry, Faculty of Medicine, Social Determinants of Health Research Center Gonabad University of Medical Science Gonabad Iran.
Department of Physiology, Faculty of Medicine Gonabad University of Medical Sciences Gonabad Iran.
Food Sci Nutr. 2024 Dec 10;13(1):e4667. doi: 10.1002/fsn3.4667. eCollection 2025 Jan.
Due to the anti-inflammatory and antioxidant properties of the and the pathological mechanisms of rhabdomyolysis in the kidney, this plant can be used to improve the symptoms of this disease. Then, in this study, we investigated the effects of this herb in improving kidney injury by rhabdomyolysis. Animals were divided into five groups: control, glycerol (received it for rhabdomyolysis induction), extract (received 12 mg/kg extract), and treatment groups with dexamethasone (0.03 mg/kg) and extract (12 mg/kg). The extract was analyzed using HNMR. After a week, blood and urine samples were taken to measure protein, urea, and creatinine. Then, the animals were sacrificed, and the kidney tissue was removed to examine the antioxidant, TNF-α, and histopathological evaluations. Also, NF-κB gene expression was investigated. The serum creatinine, TNF-α, and NF-κB ratio significantly increased and antioxidant capacity decreased in the glycerol group compared with the control. Pathological evaluation also showed severe renal damage based on the related criteria. In the treatment groups with dexamethasone and especially extract, the considered parameters attenuated relatively compared with the glycerol group. Kidney damage and functional impairment associated with rhabdomyolysis, as well as the inflammatory response caused by increased NF-κB and the proinflammatory cytokine TNF-α, may be alleviated by . Consequently, could represent a potential therapeutic approach for patients with rhabdomyolysis-induced acute kidney injury.
由于[植物名称]的抗炎和抗氧化特性以及肾脏横纹肌溶解的病理机制，这种植物可用于改善该疾病的症状。然后，在本研究中，我们研究了这种草药对改善横纹肌溶解所致肾损伤的作用。将动物分为五组：对照组、甘油组（接受甘油以诱导横纹肌溶解）、提取物组（接受12mg/kg提取物）以及地塞米松（0.03mg/kg）和提取物（12mg/kg）治疗组。使用核磁共振氢谱（HNMR）对提取物进行分析。一周后，采集血液和尿液样本以测量蛋白质、尿素和肌酐。然后，处死动物，取出肾脏组织进行抗氧化、肿瘤坏死因子-α（TNF-α）和组织病理学评估。此外，还研究了核因子-κB（NF-κB）基因表达。与对照组相比，甘油组血清肌酐、TNF-α和NF-κB比值显著升高，抗氧化能力下降。病理评估也显示根据相关标准存在严重肾损伤。在地塞米松治疗组尤其是提取物治疗组中，与甘油组相比，所考虑的参数相对减轻。横纹肌溶解相关的肾损伤和功能损害，以及由NF-κB和促炎细胞因子TNF-α增加引起的炎症反应，可能通过[植物名称]得到缓解。因此，[植物名称]可能代表一种针对横纹肌溶解诱导的急性肾损伤患者的潜在治疗方法。
