Zahary Loreman Holly E, Holfeld Karen I
University of Calgary Cumming School of Medicine, Calgary, AB, Canada.
Division of Dermatology, University of Saskatchewan College of Medicine, Saskatoon, SK, Canada.
SAGE Open Med Case Rep. 2025 Jan 9;13:2050313X241311372. doi: 10.1177/2050313X241311372. eCollection 2025.
Papulonodular mucinosis is a rare dermatological condition characterized by mucin deposition in the dermis, leading to the formation of papules and nodules that can occur with, or antedate, autoimmune connective tissue diseases. This case report presents a 67-year-old female with a chronic history of cutaneous mucinosis, which posed significant diagnostic challenges. Despite various treatments and extensive diagnostic workup, her condition evolved, highlighting the difficulties in diagnosing papulonodular mucinosis, especially in the absence of systemic lupus erythematosus and antinuclear antibody positivity. The unusual presentation and diagnostic complexity underscore the need for awareness and thorough investigation in similar cases.
丘疹结节性黏蛋白沉积症是一种罕见的皮肤病，其特征是真皮内有黏蛋白沉积，导致丘疹和结节形成，这些丘疹和结节可与自身免疫性结缔组织病同时出现或先于其出现。本病例报告介绍了一名67岁女性，有慢性皮肤黏蛋白沉积症病史，这带来了重大的诊断挑战。尽管进行了各种治疗和广泛的诊断检查，她的病情仍在发展，突出了诊断丘疹结节性黏蛋白沉积症的困难，尤其是在没有系统性红斑狼疮和抗核抗体阳性的情况下。这种不寻常的表现和诊断复杂性强调了在类似病例中提高认识和进行全面调查的必要性。
