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本文引用的文献

1
Disparities in integrating non-invasive prenatal testing into antenatal healthcare in Australia: a survey of healthcare professionals.澳大利亚将无创产前检测纳入产前保健中的差异:对医疗保健专业人员的调查。
BMC Pregnancy Childbirth. 2024 May 14;24(1):355. doi: 10.1186/s12884-024-06565-1.
2
Western Australian women's expectations for expanded NIPT-An online survey regarding NIPT for single gene, recessive and chromosomal conditions.西澳大利亚州女性对扩大无创产前检测的期望——一项关于针对单基因、隐性和染色体疾病的无创产前检测的在线调查
J Genet Couns. 2023 Oct;32(5):1047-1056. doi: 10.1002/jgc4.1715. Epub 2023 Apr 25.
3
Position statement from the International Society for Prenatal Diagnosis on the use of non-invasive prenatal testing for the detection of fetal chromosomal conditions in singleton pregnancies.国际产前诊断学会关于在单胎妊娠中使用无创产前检测来检测胎儿染色体疾病的立场声明。
Prenat Diagn. 2023 Jun;43(7):814-828. doi: 10.1002/pd.6357. Epub 2023 May 16.
4
Challenges for Medicare and universal health care in Australia since 2000.2000 年以来澳大利亚的医疗保险和全民医疗保健面临的挑战。
Med J Aust. 2023 Apr 17;218(7):322-329. doi: 10.5694/mja2.51844. Epub 2023 Feb 4.
5
Inclusion of sex chromosomes in noninvasive prenatal testing in Asia, Australia, Europe and the USA: A survey study.纳入亚洲、澳大利亚、欧洲和美国的非侵入性产前检测中的性染色体:一项调查研究。
Prenat Diagn. 2023 Feb;43(2):144-155. doi: 10.1002/pd.6322. Epub 2023 Feb 7.
6
A decade of non-invasive prenatal screening in Australia: National impact on prenatal screening and diagnostic testing.澳大利亚十年无创产前筛查:对产前筛查和诊断检测的全国性影响
Aust N Z J Obstet Gynaecol. 2023 Apr;63(2):264-267. doi: 10.1111/ajo.13638. Epub 2022 Dec 18.
7
Noninvasive prenatal screening (NIPS) for fetal chromosome abnormalities in a general-risk population: An evidence-based clinical guideline of the American College of Medical Genetics and Genomics (ACMG).一般风险人群胎儿染色体异常的无创产前筛查(NIPS):美国医学遗传学与基因组学学会(ACMG)基于证据的临床指南。
Genet Med. 2023 Feb;25(2):100336. doi: 10.1016/j.gim.2022.11.004. Epub 2022 Dec 16.
8
Systematic evidence-based review: The application of noninvasive prenatal screening using cell-free DNA in general-risk pregnancies.基于循证医学的系统评价:游离DNA无创产前筛查在一般风险妊娠中的应用
Genet Med. 2022 Sep;24(9):1992. doi: 10.1016/j.gim.2022.07.002.
9
The ethical landscape(s) of non-invasive prenatal testing in England, France and Germany: findings from a comparative literature review.英国、法国和德国的非侵入性产前检测的伦理景观:一项比较文献综述的研究结果。
Eur J Hum Genet. 2022 Jun;30(6):676-681. doi: 10.1038/s41431-021-00970-2. Epub 2021 Oct 4.
10
Non-invasive prenatal test uptake in socioeconomically disadvantaged neighborhoods.社会经济条件不利社区的无创性产前检测普及率。
Prenat Diagn. 2021 Oct;41(11):1395-1400. doi: 10.1002/pd.6043. Epub 2021 Sep 14.

“筛查不应基于支付能力”:澳大利亚医疗服务提供者和消费者对非侵入性产前检测公共资金的看法。

'Screening should not be based on ability to pay': Australian healthcare providers' and consumers' perspectives on public funding for non-invasive prenatal testing.

作者信息

Pynaker Cecilia, Johnston Molly, Mills Catherine, Vasey Katie, Taylor-Sands Michelle, Bowman-Smart Hilary, Hui Lisa

机构信息

Reproductive Epidemiology Group, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.

Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, Victoria, Australia.

出版信息

Aust N Z J Obstet Gynaecol. 2025 Jun;65(3):409-419. doi: 10.1111/ajo.13915. Epub 2025 Jan 13.

DOI:10.1111/ajo.13915
PMID:39803931
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12282033/
Abstract

BACKGROUND

Non-invasive prenatal testing (NIPT) does not receive any Medicare rebate. This study investigated the views of Australian healthcare providers and consumers on public funding of NIPT.

MATERIALS AND METHODS

Two anonymous online, cross-sectional surveys were conducted from September 2022 to January 2023. Surveys targeted maternity healthcare professionals ('providers'), and individuals who had recently conceived a pregnancy ('consumers'). Quantitative data were analysed using χ test. Free-text responses were analysed by inductive content analysis.

RESULTS

Responses from 381 providers and 630 consumers were analysed. The overwhelming majority of providers (96.8%) identified financial cost as a consumer barrier to NIPT access. Public funding for NIPT was supported by 86.4% of providers and 90.4% of consumers, with free-text responses citing equity, clinical, health economic, reproductive autonomy, and ethical justifications. Of the 145 consumers who did not use NIPT in a recent pregnancy, 63.1% rated cost as an 'important/very important' factor in foregoing NIPT. NIPT non-users were younger, had lower household income and education, and were more likely to live in a rural or remote area than consumers who used NIPT.

CONCLUSION

Maternity healthcare providers and consumers are highly supportive of public funding for NIPT as a first-line screening test on clinical, equity, health economic, and ethical grounds. Our results confirm the presence of significant socioeconomic disparities between NIPT users and non-users, with cost being the most important factor impeding equitable access to best practice in prenatal screening. Further research and advocacy are needed to achieve equitable access to best practice in antenatal care.

摘要

背景

无创产前检测(NIPT)未获得任何医疗保险回扣。本研究调查了澳大利亚医疗服务提供者和消费者对NIPT公共资金支持的看法。

材料与方法

2022年9月至2023年1月进行了两项匿名在线横断面调查。调查对象为孕产妇保健专业人员(“提供者”)和近期怀孕的个人(“消费者”)。使用χ检验分析定量数据。通过归纳性内容分析对自由文本回复进行分析。

结果

分析了381名提供者和630名消费者的回复。绝大多数提供者(96.8%)认为经济成本是消费者获取NIPT的障碍。86.4%的提供者和90.4%的消费者支持NIPT的公共资金支持,自由文本回复列举了公平性、临床、健康经济学、生殖自主权和伦理方面的理由。在最近一次怀孕中未使用NIPT的145名消费者中,63.1%将成本列为放弃NIPT的“重要/非常重要”因素。与使用NIPT的消费者相比,未使用NIPT的消费者更年轻,家庭收入和教育水平较低,且更有可能生活在农村或偏远地区。

结论

孕产妇保健提供者和消费者高度支持将NIPT作为一线筛查测试的公共资金支持,基于临床、公平性、健康经济学和伦理理由。我们的结果证实了NIPT使用者和非使用者之间存在显著的社会经济差异,成本是阻碍公平获取最佳产前筛查实践的最重要因素。需要进一步的研究和宣传,以实现公平获取最佳产前护理实践。