负责快速低密度脂蛋白内化的三元复合物成分作为与增殖和早期复发相关的乳腺癌生物标志物。
Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence.
作者信息
McDonald Elizabeth S, Pan Tien-Chi, Pant Dhruv K, Troester Melissa A, Kossenkov Andrew V, Mankoff David A, Mach Robert H, Chodosh Lewis A
机构信息
Division of Breast Imaging, Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
出版信息
Cancer Res Commun. 2025 Feb 1;5(2):226-239. doi: 10.1158/2767-9764.CRC-23-0562.
This first large-scale analysis of the putative ternary complex responsible for rapid low-density lipoprotein internalization in breast cancer reveals a link between component expression and recurrence, with prognostic implications for identifying patients needing supplemental posttreatment surveillance and/or additional therapeutic approaches.
这项对乳腺癌中负责快速低密度脂蛋白内化的假定三元复合物的首次大规模分析揭示了各组分表达与复发之间的联系，对确定需要补充治疗后监测和/或其他治疗方法的患者具有预后意义。
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