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撤回声明:热休克蛋白27与涎腺腺样囊性癌的上皮-间质转化、干性和放射抗性相关。

RETRACTION: HSP27 Associates With Epithelial-Mesenchymal Transition, Stemness and Radioresistance of Salivary Adenoid Cystic Carcinoma.

出版信息

J Cell Mol Med. 2025 Jan;29(1):e70365. doi: 10.1111/jcmm.70365.

Abstract

W. Chen, X. Ren, J. Wu, X. Gao, X. Cen, S. Wang, S. Sheng, Q. Chen, Y.-J. Tang, X.-H. Liang, and Y.-L. Tang, "HSP27 Associates with Epithelial-Mesenchymal Transition, Stemness and Radioresistance of Salivary Adenoid Cystic Carcinoma," Journal of Cellular and Molecular Medicine 22, no. 4 (2018): 2283-2298, https://doi.org/10.1111/jcmm.13510. The above article, published online on 09 February 2018 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Stefan Constantinescu; The Foundation for Cellular and Molecular Medicine; and John Wiley and Sons Ltd. The retraction has been agreed upon following an investigation into concerns raised by a third party, which revealed inappropriate image panel duplications within the article depicting different experimental conditions (Figure 1B Control and EV, Figure 2C Control and Neg, Figure 3A Control and EV, Figure 1F SACC-LM Control and CM+HSP27, and Figure 6B SACC-LM CM without IR and CM with IR panels). Additionally, irregularities were discovered regarding the appearance of the dissected tumors in Figure 5A and another instance of image duplication was identified between Figure 1F SACC-LM Control panel and another image published previously by an overlapping group of authors in a different scientific context. The explanation provided by the authors was unsatisfactory and the partial raw data shared could not address these concerns. Thus, the editors have lost confidence in the presented data and consider the conclusions of this manuscript substantially compromised. The authors disagree with the retraction wording.

摘要

W. 陈、X. 任、J. 吴、X. 高、X. 岑、S. 王、S. 盛、Q. 陈、Y.-J. 唐、X.-H. 梁和Y.-L. 唐,“热休克蛋白27与涎腺腺样囊性癌的上皮-间质转化、干性及放射抗性相关”,《细胞与分子医学杂志》22卷,第4期(2018年):2283 - 2298页,https://doi.org/10.1111/jcmm.13510 。上述文章于2018年2月9日在线发表于威利在线图书馆(wileyonlinelibrary.com),已由期刊主编斯特凡·康斯坦丁内斯库、细胞与分子医学基金会以及约翰·威利父子有限公司协商一致撤回。此次撤回是在对第三方提出的担忧进行调查后达成的,调查发现文章中描绘不同实验条件的图像面板存在不当重复(图1B对照组和空载体组、图2C对照组和阴性组、图3A对照组和空载体组、图1F SACC-LM对照组和CM + HSP27组,以及图6B SACC-LM CM无辐射组和CM有辐射组)。此外,发现图5A中解剖肿瘤的外观存在异常,并且在图1F SACC-LM对照组面板与同一作者团队先前在不同科学背景下发表的另一幅图像之间发现了另一例图像重复情况。作者提供的解释不能令人满意,所共享的部分原始数据也无法解决这些问题。因此,编辑们对所呈现的数据失去了信心,并认为该稿件的结论受到了严重损害。作者不同意撤回声明的措辞。

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