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孕妇个体尿碘浓度与母婴结局之间的关联。

Association between individual urinary iodine concentrations in pregnant women and maternal/newborn outcomes.

作者信息

Bolfi Fernanda, Marum Maryan Borcsik, Fonseca Samantha Ellen da Silva, Mazeto Glaucia M F S, Nogueira Celia Regina, Nunes-Nogueira Vania Dos Santos

出版信息

Endocr Connect. 2025 Jan 29;14(3). doi: 10.1530/EC-24-0621. Print 2025 Mar 1.

DOI:10.1530/EC-24-0621
PMID:39804211
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11799753/
Abstract

OBJECTIVE

To assess whether individual diagnosis of low urinary iodine concentration (UIC) in pregnant women is associated with adverse maternal and neonatal outcomes.

METHODS

Studies that compared pregnant women with UIC <150 μg/L and those with UIC 150-249 μg/L were systematically reviewed. MEDLINE, Embase, LILACS and CENTRAL were our source databases. Selection of studies, risk-of-bias assessment and data extraction were performed in pairs and independently. Relative risk (RR) with 95% confidence interval (CI) was calculated as an estimate of the effect of iodine <150 μg/L. Stata software was used to perform meta-analyses. The quality of evidence was determined according to the Grading of Recommendations Assessment, Development and Evaluation.

RESULTS

In total, 7000 studies were identified, of which 63 were included. With low or very low certainty of the evidence, no difference in the incidence of miscarriage (RR: 0.87, 95% CI: 0.64-1.18, 6 studies, 4855 participants), maternal hypothyroidism (RR: 1.05, 95% CI: 0.68-1.60, 10 studies, 11,773 participants), preterm birth (RR: 1.20, 95% CI: 0.97-1.48, 13 studies, 15,644 participants), stillbirths (RR: 0.79, 95% CI: 0.34-1.82, 6 studies, 3406 participants), low birth weight (RR: 1.25, 95% CI: 0.88-1.78, 10 studies, 10,775 participants) and small for gestational age (RR: 1.11, 95% CI: 0.90-1.37, 5 studies, 4266 participants) was observed between the two groups.

CONCLUSION

In pregnant women, individual diagnosis of UIC <150 μg/L was not associated with adverse maternal and neonatal outcomes, emphasizing UIC as a limited method to assess individual iodine status during pregnancy.

摘要

目的

评估孕妇个体尿碘浓度（UIC）低是否与不良母婴结局相关。

方法

系统回顾比较UIC<150μg/L的孕妇与UIC为150 - 249μg/L的孕妇的研究。MEDLINE、Embase、LILACS和CENTRAL是我们的源数据库。研究的选择、偏倚风险评估和数据提取由两人独立进行。计算95%置信区间（CI）的相对风险（RR），作为碘<150μg/L影响的估计值。使用Stata软件进行荟萃分析。根据推荐评估、制定和评价分级确定证据质量。

结果

共识别出7000项研究，其中63项被纳入。证据确定性低或非常低，两组间流产发生率（RR：0.87，95%CI：0.64 - 1.18，6项研究，4855名参与者）、母体甲状腺功能减退（RR：1.05，95%CI：0.68 - 1.60，10项研究，11773名参与者）、早产（RR：1.20，95%CI：0.97 - 1.48，13项研究，15644名参与者）、死产（RR：0.79，95%CI：0.34 - 1.82，6项研究，3406名参与者）、低出生体重（RR：1.25，95%CI：0.88 - 1.78，10项研究，10775名参与者）和小于胎龄儿（RR：1.11，95%CI：0.90 - 1.37，5项研究，4266名参与者）无差异。

结论

在孕妇中，个体诊断UIC<150μg/L与不良母婴结局无关，强调UIC作为评估孕期个体碘状态的有限方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d7a/11799753/69639686d823/EC-24-0621fig10.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d7a/11799753/1b7b04319e1f/EC-24-0621fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d7a/11799753/69639686d823/EC-24-0621fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d7a/11799753/cb8728334614/EC-24-0621fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d7a/11799753/72f7b26b8e69/EC-24-0621fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d7a/11799753/7660b9785690/EC-24-0621fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d7a/11799753/3b71e162fcfe/EC-24-0621fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d7a/11799753/61783a04d47e/EC-24-0621fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d7a/11799753/460da73f006e/EC-24-0621fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d7a/11799753/6a58a54471a3/EC-24-0621fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d7a/11799753/4150028712bc/EC-24-0621fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d7a/11799753/1b7b04319e1f/EC-24-0621fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d7a/11799753/69639686d823/EC-24-0621fig10.jpg

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Iodine Status, Thyroid Disorder and Feto-Maternal Outcome among the Tribal Pregnant Women of Eastern Himalayas.
东喜马拉雅地区部落孕妇的碘营养状况、甲状腺疾病及母婴结局
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The Relationship Between Iodine Excess and Thyroid Function During Pregnancy and Infantile Neurodevelopment at 18-24 Months.碘过量与妊娠期间甲状腺功能及婴儿 18-24 月龄神经发育的关系。
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