2型糖尿病患者中具有不确定潜能的克隆性造血与微血管并发症风险：一项队列研究

Clonal Hematopoiesis of Indeterminate Potential and Risk of Microvascular Complications Among Individuals With Type 2 Diabetes: A Cohort Study.

作者信息

Wei Jiahe, Yu Yuefeng, Wu Hanzhang, Li Yingjun, Wang Ningjian, Tan Xiao

机构信息

Department of Big Data in Health Science, Zhejiang University School of Public Health and Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Hangzhou, China.

出版信息

Diabetes. 2025 Apr 1;74(4):585-595. doi: 10.2337/db24-0841.

DOI:10.2337/db24-0841

PMID:39804667

Abstract

Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related disorder that is associated with macrovascular diseases, such as coronary artery disease and stroke. However, the effects of CHIP on microvascular complication have not been explored in individuals with type 2 diabetes. We wanted to determine whether CHIP is associated with diabetic microvascular complications (DMCs). CHIP was associated with a high risk of DMCs, specifically, diabetic retinopathy and diabetic kidney disease, but not diabetic neuropathy. Gene-specific analyses suggested that some driver genes were associated with risk of developing DMCs. These findings indicated that CHIP may represent a novel risk factor for DMCs among individuals with type 2 diabetes, distinct from traditional risk factors, which may have implications for prevention and management of DMCs.

摘要

不确定潜能的克隆性造血（CHIP）是一种与年龄相关的疾病，与冠状动脉疾病和中风等大血管疾病有关。然而，CHIP对2型糖尿病患者微血管并发症的影响尚未得到研究。我们想确定CHIP是否与糖尿病微血管并发症（DMC）相关。CHIP与DMC的高风险相关，具体而言，与糖尿病视网膜病变和糖尿病肾病相关，但与糖尿病神经病变无关。基因特异性分析表明，一些驱动基因与发生DMC的风险相关。这些发现表明，CHIP可能是2型糖尿病患者发生DMC的一个新的危险因素，与传统危险因素不同，这可能对DMC的预防和管理具有重要意义。