Wang Zi-Qian, Wu Fan, Zhong Zhi-Jian, Luo Xiao-Rong, Wan Xin-Hao, Liao Jia-Li, Tao Qing, Wu Zhen-Feng
Key Laboratory of Modern Preparations of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine Nanchang 330004, China Jiangxi Drug Inspection Center Nanchang 330000, China.
Jiangxi Drug Inspection Center Nanchang 330000, China.
Zhongguo Zhong Yao Za Zhi. 2024 Dec;49(24):6558-6564. doi: 10.19540/j.cnki.cjcmm.20240924.301.
The construction method and simulation parameter settings for the discrete element model of Jianwei Xiaoshi Granules, as the primary material of Jianwei Xiaoshi Tablets, are not yet clear. The accuracy of the simulation model significantly influences the dynamic response characteristics between granules. Therefore, it is necessary to calibrate the parameters to improve the accuracy of the simulation parameters. Using the repose angle of Jianwei Xiaoshi Granules as the response value, the response surface methodology was employed to optimize and calibrate the discrete element parameters. Physical experiments were conducted to determine the physical properties of Jianwei Xiaoshi Granules. Based on the Hertz-Mindlin with Johnson-Kendall-Roberts(JKR) V2 model and virtual simulation methods, a repose angle determination model was constructed in EDEM software. The repose angle was measured using image analysis and numerical fitting methods. The Plackett-Burman experiment was used to screen the initial parameters for significance in the discrete element simulation. The significant parameters were then subjected to a steepest ascent experiment to determine the optimal parameter range. Furthermore, based on the Box-Behnken experiment, a second-order regression equation between significant parameters and repose angle was established, with the repose angle of 37.64° in the physical experiment as the target value. The regression equation was optimized and solved. The significance screening experiment revealed that the granule-granule static friction coefficient, granule-granule rolling friction, and granule-steel plate rolling friction of Jianwei Xiaoshi Granules significantly influenced the simulated repose angle. The optimal parameter combination was found to be 0.330, 0.222, and 0.229. The simulation results with this optimal parameter combination showed that there was no significant difference between the simulated repose angle and the repose angle obtained in the physical experiment, with a relative error of 0.05%, which further validated the reliability of the calibrated discrete element parameters for Jianwei Xiaoshi Granules.
健胃消食片的主要原料健胃消食颗粒离散元模型的构建方法及模拟参数设置尚不清楚。模拟模型的准确性显著影响颗粒间的动态响应特性。因此，有必要对参数进行校准以提高模拟参数的准确性。以健胃消食颗粒的休止角为响应值，采用响应面法对离散元参数进行优化和校准。通过物理实验测定健胃消食颗粒的物理性质。基于带有约翰逊-肯德尔-罗伯茨（JKR）V2模型的赫兹-明德林理论和虚拟模拟方法，在EDEM软件中构建休止角测定模型。采用图像分析和数值拟合方法测量休止角。利用Plackett-Burman实验筛选离散元模拟中的初始显著参数。然后对显著参数进行最速上升实验以确定最佳参数范围。此外，基于Box-Behnken实验，以物理实验中37.64°的休止角为目标值，建立了显著参数与休止角之间的二阶回归方程。对回归方程进行优化求解。显著性筛选实验表明，健胃消食颗粒的颗粒间静摩擦系数、颗粒间滚动摩擦以及颗粒与钢板间的滚动摩擦对模拟休止角有显著影响。最佳参数组合为0.330、0.222和0.229。该最佳参数组合的模拟结果表明，模拟休止角与物理实验中得到的休止角之间无显著差异，相对误差为0.05%，进一步验证了校准后的健胃消食颗粒离散元参数的可靠性。
