Koivuholma Anne, Sistonen Heli J, Aro Katri, Mäkitie Antti, Hagström Jaana, Atula Timo
Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, P.O. Box 263, 00029, Helsinki, Finland.
Department of Pathology, HUSLAB, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Sci Rep. 2025 Jan 13;15(1):1888. doi: 10.1038/s41598-025-85478-1.
Three-dimensional (3D) modeling is often used to provide better visual understanding. This has become an everyday tool especially in medical imaging. However, modeling soft tissue histopathology in 3D is in its early stages, thus making 3D comparison between radiology and histopathology difficult. Here, we sought to create a model that combines a model based on histopathological tumor borders and a model reformatted from magnetic resonance image (MRI). The 3D models were constructed from an oral squamous cell carcinoma (OSCC) resection specimen and a preoperative MRI scan. Potential challenges were identified, and respective solutions proposed. The 3D model based on histopathological tumor borders was constructed by a method that uses a 3D table scanner and modeling software. The 3D MRI model was constructed using 3D Slicer software. The two models were fitted together by anatomical landmarks in each model. We compared the volume and dimensions between the two 3D models. As a result, we created an image fusion that presents the soft-tissue resection specimen, its histopathological findings, and the MRI findings combined in a digital 3D form. Presenting these two 3D models within the resection specimen can serve as a tool to improve the multidisciplinary discussion of patient management. To create these models, only a few additional steps to a normal protocol are required.
三维（3D）建模常用于提供更好的视觉理解。这已成为一种日常工具，尤其在医学成像领域。然而，软组织组织病理学的3D建模尚处于早期阶段，因此难以在放射学和组织病理学之间进行3D比较。在此，我们试图创建一个模型，该模型结合基于组织病理学肿瘤边界的模型和从磁共振图像（MRI）重新格式化的模型。3D模型由口腔鳞状细胞癌（OSCC）切除标本和术前MRI扫描构建而成。识别了潜在挑战，并提出了相应的解决方案。基于组织病理学肿瘤边界的3D模型通过使用3D桌面扫描仪和建模软件的方法构建。3D MRI模型使用3D Slicer软件构建。通过每个模型中的解剖标志将两个模型拟合在一起。我们比较了两个3D模型之间的体积和尺寸。结果，我们创建了一种图像融合，以数字3D形式呈现软组织切除标本、其组织病理学发现和MRI发现。在切除标本中展示这两个3D模型可作为一种工具，用于改善患者管理的多学科讨论。要创建这些模型，只需在正常流程中增加几个步骤即可。
