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通过身体加速度和广义沃默斯利解的联合效应研究狭窄动脉中的血流模式。

Study of blood flow patterns in a stenosed artery through the combined effect of body acceleration and generalized womersley solution.

作者信息

Udupa Mahesh C, Saha Sunanda, Natarajan Sekarapandian

机构信息

Department of Mathematics, School of Advanced Sciences, VIT, Vellore, 632014, India.

Centre for Clean Environment, VIT, Vellore, 632014, India.

出版信息

Sci Rep. 2025 Jan 13;15(1):1845. doi: 10.1038/s41598-025-85566-2.

Abstract

Stenosis causes the narrowing of arteries due to plaque buildup, which impedes blood flow and affects flow dynamics. This work numerically analyzes flow fluctuations in stenosed arteries under realistic physiological conditions (resting and exercise) and external body acceleration. The artery is inclined at angle , and blood rheology is modeled using a generalized power-law fluid. A modified two-dimensional SIMPLE pressure-correction-based numerical solver with orthogonal coordinate transformation simulates blood flow. A generalized Womersley solution is imposed at the inlet. We validate the solver and perform simulations to assess the influence of geometric and flow parameters, analyzing time-averaged and phase-averaged data. We investigate the correlation between hyperviscosity and physiological conditions, finding that exercise increases recirculation downstream of the stenosis. We also study the impact of transitioning between resting and exercise conditions, noting that the transition rate correlates with stenosis development, indicating potential complications.

摘要

狭窄是由于斑块积聚导致动脉变窄,这会阻碍血液流动并影响流动动力学。这项工作对在现实生理条件(静息和运动)以及身体外部加速度下狭窄动脉中的血流波动进行了数值分析。动脉倾斜角度为 ,血液流变学采用广义幂律流体进行建模。使用具有正交坐标变换的基于SIMPLE压力修正的改进二维数值求解器来模拟血流。在入口处施加广义沃默斯利解。我们对求解器进行了验证,并进行模拟以评估几何和流动参数的影响,分析时间平均和相位平均数据。我们研究了高粘滞血症与生理条件之间的相关性,发现运动增加了狭窄下游的再循环。我们还研究了静息和运动条件之间转换的影响,注意到转换速率与狭窄发展相关,表明存在潜在并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f176/11729896/51d3b7cb7c06/41598_2025_85566_Fig1_HTML.jpg

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