An Zihao, Wang Jiepu, Li Chengzuo, Tang Chao
National Clinical Research Center for Child Health of Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, China.
Cell Commun Signal. 2025 Jan 14;23(1):25. doi: 10.1186/s12964-024-02005-x.
CXXC type zinc finger protein 5 (CXXC5) is a member of the ZF-CXXC family and plays a pivotal role in signal integration and information transfer within cell signaling network. CXXC5 acts as a regulator in various physiological processes, and abnormalities in its protein structure or function have been linked to multiple pathological processes. In this article, we correspondingly describe the composition of the ZF-CXXC family, emphatically introducing the features of the CXXC5 gene and protein, review the role of CXXC5 in cellular signaling networks, the physiological and pathological processes associated with CXXC5 dysregulation, and particularly focus on the correlation between CXXC5 and cancers. Finally, we summarize the current therapies targeting CXXC5 and their potential applications, and discuss the intriguing findings from current studies, and the opportunities and challenges in future.
CXXC型锌指蛋白5（CXXC5）是ZF-CXXC家族的成员之一，在细胞信号网络中的信号整合和信息传递中起着关键作用。CXXC5在多种生理过程中作为调节因子发挥作用，其蛋白质结构或功能的异常与多种病理过程相关。在本文中，我们相应地描述了ZF-CXXC家族的组成，着重介绍CXXC5基因和蛋白质的特征，综述CXXC5在细胞信号网络中的作用、与CXXC5失调相关的生理和病理过程，特别关注CXXC5与癌症之间的相关性。最后，我们总结了目前针对CXXC5的治疗方法及其潜在应用，并讨论了当前研究中的有趣发现以及未来的机遇和挑战。
