Mackrell Lucy, Carter Megan, Hoover Maggie, O'Byrne Patrick, Larkin Natasha, Magpantay Felicia Maria G, Zhao Sicheng, Stoner Bradley, Richard-Greenblatt Melissa, Mandryk Kira, Belanger Kandace, Burbidge Jennifer, Charette Gilles, Deschenes Gabrielle, Dinh Duy A, Featherstone Amanda, Khandakar Farhan, Martinez-Cajas Jorge, Tran Vanessa, Szumlanski Nicole, Vance Stephanie, Saeed Sahar
Department of Public Health Sciences, Queen's University, Kingston, Ontario, Canada.
KFL&A Public Health, Kingston, Ontario, Canada.
BMJ Open. 2024 Dec 20;14(12):e089021. doi: 10.1136/bmjopen-2024-089021.
Urgent, tailored and equitable action is needed to address the alarming rise in syphilis rates in Canada. In the last decade, the rates of infectious syphilis have increased by 345% in Ontario, Canada. Underserved populations-people who use drugs, un(der)housed individuals and those living in rural and remote areas-face unique social and healthcare challenges that increase their vulnerability to syphilis infections and hinder their access to timely diagnosis and treatment. This study assesses the real-world implementation and effectiveness of using a recently approved syphilis point-of-care test in conjunction with public health outreach to break barriers and bring services to the population at the highest risk.
The Syphilis Rapid Point-of-Care Testing and Immediate Treatment Evaluation (SPRITE) study includes eight public health units in Ontario, Canada. Implementation and evaluation of this rapid 'test and treat' outreach model of care will be assessed using the Practical, Robust Implementation and Sustainability Model (PRISM)/Reach, Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) Framework, following a community-based participatory approach. Network models will be used to estimate the population-level impact of implementing this model of care to curb transmission. Knowledge mobilisation will be assessed using the Reciprocity, Externalities, Access, and Partnership (REAP) Self-Assessment Model.
The SPRITE study was approved by the Queen's University Research Ethics Board (REB) and is to be conducted in accordance with the Canadian Tri-Council Policy Statement V.2 and the latest Seoul revision of the Declaration of Helsinki. Knowledge generated from this study will be mobilised through community-based organisations and the broader public health community.
需要采取紧急、有针对性且公平的行动，以应对加拿大梅毒发病率惊人上升的问题。在过去十年中，加拿大安大略省的感染性梅毒发病率增长了345%。服务不足的人群——吸毒者、无家可归者以及生活在农村和偏远地区的人——面临着独特的社会和医疗挑战，这些挑战增加了他们感染梅毒的易感性，并阻碍他们及时获得诊断和治疗。本研究评估了使用最近批准的梅毒即时检测方法并结合公共卫生外展服务，以打破障碍并为风险最高的人群提供服务的实际实施情况和效果。
梅毒快速即时检测与即时治疗评估（SPRITE）研究包括加拿大安大略省的八个公共卫生单位。将采用基于社区的参与式方法，使用实用、稳健实施与可持续性模型（PRISM）/覆盖范围、有效性、采用、实施、维持（RE-AIM）框架，对这种快速“检测与治疗”外展护理模式的实施和评估进行评估。网络模型将用于估计实施这种护理模式对遏制传播的人群层面影响。知识传播将使用互惠、外部性、获取和伙伴关系（REAP）自我评估模型进行评估。
SPRITE研究已获得女王大学研究伦理委员会（REB）的批准，并将按照加拿大三理事会政策声明V.2和《赫尔辛基宣言》的最新首尔修订版进行。本研究产生的知识将通过社区组织和更广泛的公共卫生社区进行传播。
