Poonia Anju, Tiwari Deepak Kumar, Saharan Sandeep, Arora Neeraj, Kumar Gaurav, Kumar Tarun
Department of Veterinary Surgery and Radiology, College of Veterinary Sciences, Guru Angad Dev University of Veterinary and Animal Sciences, Ludhiana, India.
Department of Veterinary Surgery and Radiology, College of Veterinary Sciences, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, India.
Vet Res Forum. 2024;15(11):591-597. doi: 10.30466/vrf.2024.2019897.4130. Epub 2024 Nov 15.
Cardiovascular and respiratory alterations during anesthesia are of major concern in canines. Thus, it is essential to understand the potential depressant effects of anesthetic drugs on cardio-vascular system; so that, anesthetic procedures are conducted in the best possible way. The objective of the study was to assess and compare the echocardiographic indices during dex-medetomidine and midazolam anesthesia in dogs undergoing elective ovariohysterectomy. Twenty-eight female dogs brought to the department for elective ovariohysterectomy were randomly divided into two groups comprising of 14 each. Sedation was achieved with dex-medetomidine and G. Physiological parameters and echocardiographic indices were evaluated before drug administration (T), after 10 min of sedation (T), after induction (T) and at the end of surgery (T) in both groups. Heart rate was significantly higher at T, T and T; while, rectal temperature was significantly lower at T in G compared to the G There was a significant decrease in stroke volume and cardiac output values at T and then, a significant increase at T; whereas, there was a non-significant decrease at T in both groups. Ejection fraction and fractional shortening values decreased significantly at T, increased significantly at T and then, decreased significantly at the end of surgery (T). Dexmedetomidine-ketamine and midazolam-ketamine combinations provide better hemodynamic and respiratory stability in the dogs undergoing elective ovariohysterectomy. Systolic functions were minimally altered with G compared to G. Thus, G is more cardio stable compared to G.
麻醉期间犬类的心血管和呼吸变化是主要关注点。因此，了解麻醉药物对心血管系统的潜在抑制作用至关重要，以便以最佳方式进行麻醉程序。本研究的目的是评估和比较在接受择期卵巢子宫切除术的犬只中，右美托咪定和咪达唑仑麻醉期间的超声心动图指标。二十八只带到科室接受择期卵巢子宫切除术的雌性犬被随机分为两组，每组十四只。用右美托咪定和生理盐水实现镇静。在两组中，于给药前（T0）、镇静10分钟后（T1）、诱导后（T2）和手术结束时（T3）评估生理参数和超声心动图指标。与G2组相比，G1组在T1、T2和T3时心率显著更高；而在T3时，G1组直肠温度显著更低。每搏量和心输出量值在T2时显著降低，然后在T3时显著增加；而在T1时两组均有非显著降低。射血分数和缩短分数值在T1时显著降低，在T2时显著增加，然后在手术结束时（T3）显著降低。右美托咪定-氯胺酮和咪达唑仑-氯胺酮组合在接受择期卵巢子宫切除术的犬只中提供更好的血流动力学和呼吸稳定性。与G2组相比，G1组对收缩功能的影响最小。因此，与G2组相比，G1组心脏更稳定。
