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洛杉矶一家大型学术机构中西班牙裔非小细胞肺癌患者间变性淋巴瘤激酶改变的真实世界发病率

Real-World Incidence of Anaplastic Lymphoma Kinase Alterations in Hispanics with Non-Small Cell Lung Cancer at a Large Academic Institution in Los Angeles.

作者信息

Poei Darin, Ali Sana, Thomas Jacob S, Nieva Jorge J, Hsu Robert C

机构信息

Department of Medicine, University of Southern California, Los Angeles, California.

Division of Medical Oncology, Department of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California.

出版信息

Cancer Res Commun. 2025 Feb 1;5(2):277-286. doi: 10.1158/2767-9764.CRC-24-0504.

DOI:10.1158/2767-9764.CRC-24-0504
PMID:39807831
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11808653/
Abstract

This study identified a higher incidence of ALK alterations in Hispanic patients with NSCLC (12.76%) compared with that in non-Hispanic patients (5.36%) treated at a large academic center in Los Angeles, highlighting the impact of race on molecular alteration profiles and emphasizing the need to increase access to molecular analyses for this population. The variability in mutational alterations may be influenced by biological and environmental factors.

摘要

这项研究发现，在洛杉矶一家大型学术中心接受治疗的非小细胞肺癌（NSCLC）西班牙裔患者中，ALK改变的发生率（12.76%）高于非西班牙裔患者（5.36%），这突出了种族对分子改变谱的影响，并强调了增加该人群分子分析可及性的必要性。突变改变的变异性可能受生物学和环境因素影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4607/11808653/9fe86acc4de0/crc-24-0504_f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4607/11808653/305c304ca80d/crc-24-0504_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4607/11808653/9fe86acc4de0/crc-24-0504_f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4607/11808653/305c304ca80d/crc-24-0504_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4607/11808653/9fe86acc4de0/crc-24-0504_f2.jpg

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本文引用的文献

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Evaluation of the Immune Response within the Tumor Microenvironment in African American and Non-Hispanic White Patients with Non-Small Cell Lung Cancer.评估非小细胞肺癌非裔美国人和非西班牙裔白种人患者肿瘤微环境中的免疫反应。
Cancer Epidemiol Biomarkers Prev. 2024 Sep 3;33(9):1220-1228. doi: 10.1158/1055-9965.EPI-24-0333.
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Disparities in Stage at Presentation Among Hispanic and Latinx Patients With Non-Small-Cell Lung Cancer in the United States.美国非小细胞肺癌西班牙裔和拉丁裔患者在就诊时的分期差异。
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Impact of Concurrent Genomic Alterations on Clinical Outcomes in Patients With ALK-Rearranged NSCLC.ALK 重排 NSCLC 患者中同时存在的基因组改变对临床结局的影响。
J Thorac Oncol. 2024 Jan;19(1):119-129. doi: 10.1016/j.jtho.2023.08.007. Epub 2023 Aug 10.
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Racial disparity in tumor microenvironment and distant recurrence in residual breast cancer after neoadjuvant chemotherapy.新辅助化疗后残留乳腺癌的肿瘤微环境与远处复发的种族差异。
NPJ Breast Cancer. 2023 Jun 13;9(1):52. doi: 10.1038/s41523-023-00547-w.
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A review of ancestrality and admixture in Latin America and the caribbean focusing on native American and African descendant populations.对拉丁美洲和加勒比地区的祖先起源与混合情况的综述，重点关注美洲原住民和非洲裔后代群体。
Front Genet. 2023 Jan 19;14:1091269. doi: 10.3389/fgene.2023.1091269. eCollection 2023.
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Actionable mutations in non-small cell lung cancer in patients at hospital de Especialidades Eugenio Espejo, Ecuador 2017-2020.厄瓜多尔埃斯皮诺医院 2017-2020 年非小细胞肺癌患者的可操作突变。
Drug Metab Pers Ther. 2022 Dec 26;38(2):149-153. doi: 10.1515/dmpt-2022-0112. eCollection 2023 Jun 1.
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Evaluating Real World Mutational Differences Between Hispanics and Asians in NSCLC at a Large Academic Institution in Los Angeles.评估洛杉矶一所大型学术机构中 NSCLC 患者的西班牙裔和亚裔之间的真实世界突变差异。
Clin Lung Cancer. 2022 Nov;23(7):e443-e452. doi: 10.1016/j.cllc.2022.06.007. Epub 2022 Jul 4.
9
Real-world evaluation of molecular testing and treatment patterns for EGFR mutations in non-small cell lung cancer in Latin America.拉丁美洲非小细胞肺癌中表皮生长因子受体（EGFR）突变的分子检测与治疗模式的真实世界评估
Mol Clin Oncol. 2022 Jan;16(1):6. doi: 10.3892/mco.2021.2439. Epub 2021 Nov 12.
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Anaplastic lymphoma kinase rearrangement prevalence in patients with advanced non-small cell lung cancer in the United States: retrospective real world data.美国晚期非小细胞肺癌患者间变性淋巴瘤激酶重排的患病率：回顾性真实世界数据
Oncotarget. 2021 Nov 9;12(23):2308-2315. doi: 10.18632/oncotarget.28114.