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洛杉矶一家大型学术机构中西班牙裔非小细胞肺癌患者间变性淋巴瘤激酶改变的真实世界发病率

Real-World Incidence of Anaplastic Lymphoma Kinase Alterations in Hispanics with Non-Small Cell Lung Cancer at a Large Academic Institution in Los Angeles.

作者信息

Poei Darin, Ali Sana, Thomas Jacob S, Nieva Jorge J, Hsu Robert C

机构信息

Department of Medicine, University of Southern California, Los Angeles, California.

Division of Medical Oncology, Department of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California.

出版信息

Cancer Res Commun. 2025 Feb 1;5(2):277-286. doi: 10.1158/2767-9764.CRC-24-0504.

Abstract

This study identified a higher incidence of ALK alterations in Hispanic patients with NSCLC (12.76%) compared with that in non-Hispanic patients (5.36%) treated at a large academic center in Los Angeles, highlighting the impact of race on molecular alteration profiles and emphasizing the need to increase access to molecular analyses for this population. The variability in mutational alterations may be influenced by biological and environmental factors.

摘要

这项研究发现,在洛杉矶一家大型学术中心接受治疗的非小细胞肺癌(NSCLC)西班牙裔患者中,ALK改变的发生率(12.76%)高于非西班牙裔患者(5.36%),这突出了种族对分子改变谱的影响,并强调了增加该人群分子分析可及性的必要性。突变改变的变异性可能受生物学和环境因素影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4607/11808653/305c304ca80d/crc-24-0504_f1.jpg

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