Zhang Jianwei, Wu Ruoya, Mo Liyan, Ding Jinlong, Huang Ke
Shaoxing Maternity and Child Health Care Hospital, Shaoxing, China.
Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Microbiol Spectr. 2025 Feb 4;13(2):e0100124. doi: 10.1128/spectrum.01001-24. Epub 2025 Jan 14.
This study investigated the impact of the coronavirus disease 2019 (COVID-19) pandemic and its associated restrictive measures on infections in children with acute respiratory tract infection. The study aimed to elucidate the epidemiological characteristics of infections before and during the pandemic and following the easing of restrictive measures. Pharyngeal secretions were collected from 1,0174 pediatric patients with acute respiratory infection (ARI) who were admitted to Shaoxing Maternity and Child Health Care Hospital (Shaoxing, China) between May 2018 and December 2023. The analysis concentrated on detection rates, epidemiological features, and clinical characteristics. Among 10,174 samples collected from 2018 to 2023, 1,060 strains of were detected, resulting in an overall positive rate of 10.42% ( = 1,060 out of 1,0176). Further breakdown revealed positive rates of 8.25% ( = 279 out of 3,381) in phase I (May 2018-December 2019), 2.40% ( = 87 out of 3,623) in phase II (January 2020-November 2022), and 21.89% ( = 694 out of 3,170) in phase III (December 2022-December 2023). In comparison to phase I, a noteworthy decline in the positive rate of was found during phase II, followed by a substantial increase during phase III ( < 0.05). Furthermore, the positive rate of exhibited a significantly greater surge during the summer-autumn period in contrast to the winter-spring ( < 0.05). Additionally, the risk of infection in children who aged 7 years surpassed that of the age group of 0-3 years. Throughout the phases preceding, during, and after the COVID-19 pandemic, discernible fluctuations in both age distribution and seasonality of infections were identified among hospitalized children with ARI in the East China.
The resemblance between the transmission pathways of and those of COVID-19 suggests that non-pharmaceutical interventions may have comparable effects on both. This study aimed to analyze the epidemiological characteristics of children with infections in Shaoxing, China, from 2018 to 2023. This study explored how the COVID-19 pandemic has influenced the prevalence of and provided guidance for disease treatment and infection prevention.
本研究调查了2019年冠状病毒病（COVID-19）大流行及其相关限制措施对急性呼吸道感染儿童感染情况的影响。该研究旨在阐明大流行之前、期间以及限制措施放宽后的感染流行病学特征。收集了2018年5月至2023年12月期间入住绍兴市妇幼保健院（中国绍兴）的10174例急性呼吸道感染（ARI）儿科患者的咽部分泌物。分析集中在检测率、流行病学特征和临床特征上。在2018年至2023年收集的10174份样本中，检测到1060株，总体阳性率为10.42%（10176份样本中的1060份）。进一步细分显示，第一阶段（2018年5月至2019年12月）阳性率为8.25%（3381份样本中的279份），第二阶段（2020年1月至2022年11月）为2.40%（3623份样本中的87份），第三阶段（2022年12月至2023年12月）为21.89%（3170份样本中的694份）。与第一阶段相比，第二阶段的阳性率显著下降，随后在第三阶段大幅上升（P<0.05）。此外，与冬春季节相比，夏秋季节的阳性率上升更为显著（P<0.05）。此外，7岁儿童感染的风险超过了0至3岁年龄组。在COVID-19大流行之前、期间和之后的各个阶段，华东地区住院ARI儿童的感染年龄分布和季节性均出现了明显波动。
与COVID-19的传播途径相似表明，非药物干预措施可能对两者产生类似影响。本研究旨在分析2018年至2023年中国绍兴感染儿童的流行病学特征。本研究探讨了COVID-19大流行如何影响的流行情况，并为疾病治疗和感染预防提供指导。
