PIN1脯氨酰异构酶通过SREBP2介导的胆固醇生物合成途径促进膀胱癌的发生和发展。
PIN1 Prolyl Isomerase Promotes Initiation and Progression of Bladder Cancer through the SREBP2-Mediated Cholesterol Biosynthesis Pathway.
作者信息
Wang Xue, Lee Derrick, Xu Haibo, Sui Yuan, Meisenhelder Jill, Hunter Tony
机构信息
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California.
Division of Regenerative Medicine, Department of Medicine, University of California San Diego, San Diego, California.
出版信息
Cancer Discov. 2025 Mar 3;15(3):633-655. doi: 10.1158/2159-8290.CD-24-0866.
Abstract
This study provides deeper insights into the regulatory role of the phospho-dependent prolyl isomerase PIN1 in bladder cancer. The identification of the link between PIN1 and SREBP2-mediated transcription and cholesterol biosynthesis offers the potential for developing novel therapeutic strategies for bladder cancer.
摘要
本研究对磷酸化依赖性脯氨酰异构酶PIN1在膀胱癌中的调控作用提供了更深入的见解。PIN1与SREBP2介导的转录及胆固醇生物合成之间联系的确定为开发膀胱癌新的治疗策略提供了可能性。
相似文献
1
PIN1 Prolyl Isomerase Promotes Initiation and Progression of Bladder Cancer through the SREBP2-Mediated Cholesterol Biosynthesis Pathway.PIN1脯氨酰异构酶通过SREBP2介导的胆固醇生物合成途径促进膀胱癌的发生和发展。
Cancer Discov. 2025 Mar 3;15(3):633-655. doi: 10.1158/2159-8290.CD-24-0866.
2
Copy number amplification of TTPAL promotes cholesterol biosynthesis and esophageal squamous cell carcinoma progression via elevating NSUN2-mediated m5C modification of SREBP2 mRNA.TTPAL的拷贝数扩增通过提高NSUN2介导的SREBP2 mRNA的m5C修饰促进胆固醇生物合成和食管鳞状细胞癌进展。
J Exp Clin Cancer Res. 2025 Jul 26;44(1):220. doi: 10.1186/s13046-025-03483-8.
3
MiR-181a-driven downregulation of cholesterol biosynthesis through SREBP2 inhibition suppresses uveal melanoma metastasis.通过抑制SREBP2，miR-181a驱动的胆固醇生物合成下调抑制葡萄膜黑色素瘤转移。
J Exp Clin Cancer Res. 2025 Jul 19;44(1):215. doi: 10.1186/s13046-025-03459-8.
4
Tumor necrosis factor alpha-induced activation of SREBP2 promotes cholesterol biosynthesis in cholestasis.肿瘤坏死因子α诱导的SREBP2激活促进胆汁淤积时的胆固醇生物合成。
Biochim Biophys Acta Mol Cell Biol Lipids. 2025 Aug;1870(6):159642. doi: 10.1016/j.bbalip.2025.159642. Epub 2025 Jun 6.
5
Covalent Inhibition of the Peptidyl-Prolyl Isomerase Pin1 by Sulfopin Results in a Broad Impact on the Phosphoproteome of Human Osteosarcoma U2-OS Cells.磺哌嗪对肽基脯氨酰异构酶Pin1的共价抑制作用对人骨肉瘤U2-OS细胞的磷酸化蛋白质组产生广泛影响。
Proteomics. 2025 Jun 23:e13980. doi: 10.1002/pmic.13980.
6
Targeting SREBP2 in cancer progression: Molecular mechanisms, oncogenic crosstalk, and therapeutic interventions.在癌症进展中靶向SREBP2：分子机制、致癌串扰及治疗干预
Cell Signal. 2025 Nov;135:112044. doi: 10.1016/j.cellsig.2025.112044. Epub 2025 Aug 4.
7
The central role of Pin1 in age-related cancer signaling pathways.Pin1在与年龄相关的癌症信号通路中的核心作用。
Semin Cancer Biol. 2025 Sep;114:173-194. doi: 10.1016/j.semcancer.2025.05.011. Epub 2025 May 22.
8
Pin1: Advances in pancreatic cancer therapeutic potential and inhibitors research.Pin1：胰腺癌治疗潜力与抑制剂研究进展
Bioorg Chem. 2024 Dec;153:107869. doi: 10.1016/j.bioorg.2024.107869. Epub 2024 Oct 11.
9
m6A-YTHDF1 Mediated Regulation of GRIN2D in Bladder Cancer Progression and Aerobic Glycolysis.m6A-YTHDF1介导的GRIN2D在膀胱癌进展及有氧糖酵解中的调控作用
Biochem Genet. 2024 Jun 29. doi: 10.1007/s10528-024-10875-6.
10
FASN promotes the stemness of cancer stem cells and protects colorectal cancer cells from ferroptosis by inhibiting the activation of SREBP2.脂肪酸合酶（FASN）通过抑制固醇调节元件结合蛋白2（SREBP2）的激活来促进癌症干细胞的干性，并保护结肠直肠癌细胞免受铁死亡。
Front Immunol. 2025 Aug 18;16:1611375. doi: 10.3389/fimmu.2025.1611375. eCollection 2025.
本文引用的文献
1
Cancer statistics, 2024.2024年癌症统计数据。
CA Cancer J Clin. 2024 Jan-Feb;74(1):12-49. doi: 10.3322/caac.21820. Epub 2024 Jan 17.
2
Epidemiology of Bladder Cancer in 2023: A Systematic Review of Risk Factors.2023 年膀胱癌的流行病学：危险因素的系统评价。
Eur Urol. 2023 Aug;84(2):176-190. doi: 10.1016/j.eururo.2023.03.029. Epub 2023 May 16.
3
Key events in cancer: Dysregulation of SREBPs.癌症中的关键事件：固醇调节元件结合蛋白的失调
Front Pharmacol. 2023 Mar 8;14:1130747. doi: 10.3389/fphar.2023.1130747. eCollection 2023.
4
Sterol regulatory element-binding protein 2 maintains glioblastoma stem cells by keeping the balance between cholesterol biosynthesis and uptake.固醇调节元件结合蛋白 2 通过维持胆固醇生物合成和摄取之间的平衡来维持神经胶质瘤干细胞。
Neuro Oncol. 2023 Sep 5;25(9):1578-1591. doi: 10.1093/neuonc/noad060.
5
Her-2 Targeted Therapy in Advanced Urothelial Cancer: From Monoclonal Antibodies to Antibody-Drug Conjugates.人表皮生长因子受体 2 靶向治疗在晚期尿路上皮癌中的应用：从单克隆抗体到抗体药物偶联物。
Int J Mol Sci. 2022 Oct 21;23(20):12659. doi: 10.3390/ijms232012659.
6
Lipid metabolism in pancreatic cancer: emerging roles and potential targets.胰腺癌中的脂代谢：新出现的作用和潜在靶点。
Cancer Commun (Lond). 2022 Dec;42(12):1234-1256. doi: 10.1002/cac2.12360. Epub 2022 Sep 15.
7
An update on antibody-drug conjugates in urothelial carcinoma: state of the art strategies and what comes next.尿路上皮癌中抗体药物偶联物的最新进展：最新策略及未来发展方向。
Cancer Chemother Pharmacol. 2022 Sep;90(3):191-205. doi: 10.1007/s00280-022-04459-7. Epub 2022 Aug 11.
8
Zero-preserving imputation of single-cell RNA-seq data.单细胞 RNA-seq 数据的零保留插补。
Nat Commun. 2022 Jan 11;13(1):192. doi: 10.1038/s41467-021-27729-z.
9
Alteration in glycolytic/cholesterogenic gene expression is associated with bladder cancer prognosis and immune cell infiltration.糖酵解/胆固醇生成基因表达的改变与膀胱癌预后和免疫细胞浸润有关。
BMC Cancer. 2022 Jan 3;22(1):2. doi: 10.1186/s12885-021-09064-0.
10
Single-cell RNA sequencing reveals the epithelial cell heterogeneity and invasive subpopulation in human bladder cancer.单细胞 RNA 测序揭示了人类膀胱癌上皮细胞的异质性和侵袭亚群。
Int J Cancer. 2021 Dec 15;149(12):2099-2115. doi: 10.1002/ijc.33794. Epub 2021 Sep 16.
Zotero 插件