Utpal Biswajit Kumar, Roy Sajib Chandra, Zehravi Mehrukh, Sweilam Sherouk Hussein, Raja A Dinesh, Haque M Akiful, Nayak Chandan, Balakrishnan Senthilkumar, Singh Laliteshwar Pratap, Panigrahi Saswati, Alshehri Mohammed Ali, Rab Safia Obaidur, Minhaj Najmus Sakib, Emran Talha Bin
Department of Pharmacy, Faculty of Health and Life Sciences, Daffodil International University, Dhaka, Bangladesh.
Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh.
Animal Model Exp Med. 2025 Feb;8(2):266-286. doi: 10.1002/ame2.12525. Epub 2025 Jan 14.
Polyphenols, a diverse group of naturally occurring compounds found in plants, have garnered significant attention for their potential therapeutic properties in treating neurodegenerative diseases (NDs). The Wnt/β-catenin (WβC) signaling pathway, a crucial player in neurogenesis, neuronal survival, and synaptic plasticity, is involved in several cellular mechanisms related to NDs. Dysregulation of this pathway is a hallmark in the development of various NDs. This study explores multiple polyphenolic compounds, such as flavonoids, stilbenes, lignans, and phenolic acids, and their potential to protect the nervous system. It provides a comprehensive analysis of their effects on the WβC pathway, elucidating their modes of action. The study highlights the dual function of polyphenols in regulating and protecting the nervous system, providing reassurance about the research benefits. This review provides a comprehensive analysis of the results obtained from both in vitro studies and in vivo research, shedding light on how these substances influence the various components of the pathway. The focus is mainly on the molecular mechanisms that allow polyphenols to reduce oxidative stress, inflammation, and apoptotic processes, ultimately improving the function and survival of neurons. This study aims to offer a thorough understanding of the potential of polyphenols in targeting the WβC signaling pathway, which could lead to the development of innovative therapeutic options for NDs.
多酚是一类在植物中天然存在的多种化合物，因其在治疗神经退行性疾病（NDs）方面的潜在治疗特性而备受关注。Wnt/β-连环蛋白（WβC）信号通路是神经发生、神经元存活和突触可塑性的关键参与者，它参与了与NDs相关的多种细胞机制。该通路的失调是各种NDs发展的一个标志。本研究探索了多种多酚类化合物，如黄酮类、芪类、木脂素类和酚酸类，以及它们保护神经系统的潜力。它对这些化合物对WβC通路的影响进行了全面分析，阐明了它们的作用方式。该研究突出了多酚在调节和保护神经系统方面的双重功能，为研究益处提供了保障。这篇综述对体外研究和体内研究获得的结果进行了全面分析，揭示了这些物质如何影响该通路的各个组成部分。重点主要在于使多酚能够减少氧化应激、炎症和凋亡过程，最终改善神经元功能和存活的分子机制。本研究旨在全面了解多酚靶向WβC信号通路的潜力，这可能会为NDs开发创新的治疗选择。
