Croce Enrico, Simonelli Gabriele, Ferrara Maria, Escelsior Andrea, Folesani Federica, Bovio Anna, Muscettola Angela, Toffanin Tommaso, De Bellis Giovanni Antonio, Nanni Maria Giulia, Caruso Rosangela, Belvederi Murri Martino, Grassi Luigi
Integrated Department of Mental Health and Pathological Addictions, Health Trust Ferrara, Ferrara, Italy.
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy.
J Nerv Ment Dis. 2024 Dec 1;212(12):603-622. doi: 10.1097/NMD.0000000000001810.
This review aimed at summarizing the literature evidence on clinical, cognitive, and neurobiological correlates of impaired timing abilities in schizophrenia (SCZ). Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a systematic literature search was conducted in PubMed, EMBASE, and PsycInfo by looking at correlates between timing abilities and either symptom severity, cognition, and neurobiological data (imaging and electroencephalography) in individuals with SCZ, without restrictions on study design. A total of 45 articles were selected: associations were identified between impaired timing performance and positive, negative, and disorganization symptoms, as well as with executive functioning, working memory, and attention. Timing impairments were associated with altered motor coordination neural circuits. Despite high methodological and clinical heterogeneity, timing dysfunction may be associated with the symptom severity and cognitive impairments in SCZ. Further studies are needed to clarify the pathophysiology of this association and offer new therapeutic targets.
本综述旨在总结关于精神分裂症（SCZ）患者时间感知能力受损的临床、认知和神经生物学相关性的文献证据。按照系统评价和Meta分析的首选报告项目指南，在PubMed、EMBASE和PsycInfo数据库中进行了系统的文献检索，研究SCZ患者时间感知能力与症状严重程度、认知以及神经生物学数据（影像学和脑电图）之间的相关性，对研究设计不设限制。共筛选出45篇文章：时间感知能力受损与阳性、阴性和紊乱症状以及执行功能、工作记忆和注意力之间存在关联。时间感知障碍与运动协调神经回路改变有关。尽管存在高度的方法学和临床异质性，但时间感知功能障碍可能与SCZ的症状严重程度和认知障碍有关。需要进一步研究来阐明这种关联的病理生理学并提供新的治疗靶点。
