Torres-Sánchez Pablo, Lerendegui-Marco Jorge, Balibrea-Correa Javier, Babiano-Suárez Víctor, Gameiro Bernardo, Ladarescu Ion, Álvarez-Rodríguez Patricia, Daugas Jean-Michel, Koester Ulli, Michelagnoli Caterina, Pedrosa-Rivera María, Porras Ignacio, Ruiz-Magaña Ma José, Ruiz-Ruiz Carmen, Domingo-Pardo César
Instituto de Física Corpuscular (CSIC-Universidad de Valencia), Valencia, Spain.
Instituto de Física Corpuscular (CSIC-Universidad de Valencia), Valencia, Spain.
Appl Radiat Isot. 2025 Mar;217:111649. doi: 10.1016/j.apradiso.2024.111649. Epub 2024 Dec 25.
This paper explores the adaptation and application of i-TED Compton imagers for real-time dosimetry in Boron Neutron Capture Therapy (BNCT). The i-TED array, previously utilized in nuclear astrophysics experiments at CERN, is being optimized for detecting and imaging 478 keV gamma-rays, critical for accurate BNCT dosimetry. Detailed Monte Carlo simulations were used to optimize the i-TED detector configuration and enhance its performance in the challenging radiation environment typical of BNCT. Additionally, advanced 3D image reconstruction algorithms, including a combination of back-projection and List-Mode Maximum Likelihood Expectation Maximization (LM-MLEM), are implemented and validated through simulations. Preliminary experimental tests at the Institut Laue-Langevin (ILL) demonstrate the potential of i-TED in simplified conditions, with ongoing experiments focusing on testing imaging capabilities in realistic BNCT conditions.
本文探讨了i-TED康普顿成像仪在硼中子俘获疗法（BNCT）实时剂量测定中的适应性和应用。i-TED阵列此前用于欧洲核子研究组织（CERN）的核天体物理实验，目前正在针对检测和成像478 keV伽马射线进行优化，这对于精确的BNCT剂量测定至关重要。详细的蒙特卡罗模拟用于优化i-TED探测器配置，并在BNCT典型的具有挑战性的辐射环境中提高其性能。此外，还实施了包括反投影和列表模式最大似然期望最大化（LM-MLEM）相结合的先进3D图像重建算法，并通过模拟进行了验证。劳厄-朗之万研究所（ILL）的初步实验测试证明了i-TED在简化条件下的潜力，正在进行的实验专注于测试在实际BNCT条件下的成像能力。
