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Castor单分支支架型人工血管与原位开窗术治疗累及左锁骨下动脉的Stanford B型主动脉夹层的临床疗效比较:一项回顾性病例对照研究。

Comparison of clinical outcomes between Castor single-branched stent graft and in situ fenestration in treating Stanford type B aortic dissection involving the left subclavian artery: A retrospective case-control study.

作者信息

Weng Xiang, Zhang Teng, Hu YiLiang, Li XianGui, Zhou Weimin

机构信息

Department of Vascular Surgery, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University.

出版信息

Medicine (Baltimore). 2024 Nov 22;103(47):e40623. doi: 10.1097/MD.0000000000040623.

Abstract

Stanford type B aortic dissection involving the left subclavian artery (LSA) poses significant clinical challenges. The Castor single-branch stent graft and in situ fenestration are commonly used techniques, but the better endovascular treatment remains debated. This study evaluates the clinical effects of the Castor single-branched stent graft versus in situ fenestration in treating Stanford type B aortic dissection involving the LSA. We selected 75 patients with Stanford type B aortic dissection involving the LSA, admitted to the Second Affiliated Hospital of Nanchang University from January 2018 to May 2022. All patients underwent thoracic endovascular aortic repair; 34 received the Castor single-branched stent graft, while 41 underwent in situ fenestration. Clinical efficacy and perioperative complications were compared. The technical success rate of the Castor single-branch stent graft was significantly higher than that of in situ fenestration (97.06% vs 80.49%, P = .04). The Castor group exhibited significantly better outcomes in operative time (136.45 ± 25.53 min vs 157.08 ± 18.14 min), LSA blood flow recovery time (6.8 ± 2.3 min vs 20.1 ± 9.8 min), blood loss (29.03 ± 9.78 mL vs 35.69 ± 10.77 mL), contrast medium usage (288.71 ± 72.70 mL vs 352.78 ± 81.02 mL), and immediate postoperative endoleaks (1/34 vs 7/41) (P < .05). Stroke incidence (1/34 vs 2/41) and perioperative mortality (0/34 vs 1/41) were similar (P > .05). Hospital stays were comparable (15.71 ± 6.04 days vs 14.22 ± 5.01 days, P = .28). However, the cost of medical supplies (154,168.62 ± 28,288.44 CNY vs 119,589.72 ± 34,199.67 CNY) and total hospital expenses (192,665.88 ± 40,027.99 CNY vs 153,920.47 ± 42,670.87 CNY) were significantly higher in the Castor group (P < .05). The median follow-up time was 9 months (1-60 months). Follow-up showed similar 30-day postoperative mortality (1/41 vs 0/34, P = 1.00), stent patency (33/34 vs 39/41, P = .67), and stent migration rates (0/34 vs 1/41, P = 1.00). However, the endoleak rate was significantly higher in the in situ fenestration group (11/41 vs 1/34, P = .01). Both the Castor single-branch stent graft and the in situ fenestration technique effectively protect and reconstruct the LSA in Stanford type B aortic dissection, with the Castor single-branch stent graft showing higher technical success and fewer complications, indicating better clinical potential.

摘要

累及左锁骨下动脉(LSA)的Stanford B型主动脉夹层带来了重大的临床挑战。Castor单分支支架移植物和原位开窗术是常用的技术,但哪种更好的血管内治疗方法仍存在争议。本研究评估了Castor单分支支架移植物与原位开窗术治疗累及LSA的Stanford B型主动脉夹层的临床效果。我们选择了2018年1月至2022年5月在南昌大学第二附属医院住院的75例累及LSA的Stanford B型主动脉夹层患者。所有患者均接受胸主动脉腔内修复术;34例接受Castor单分支支架移植物治疗,41例接受原位开窗术。比较了临床疗效和围手术期并发症。Castor单分支支架移植物的技术成功率显著高于原位开窗术(97.06%对80.49%,P = 0.04)。Castor组在手术时间(136.45 ± 25.53分钟对157.08 ± 18.14分钟)、LSA血流恢复时间(6.8 ± 2.3分钟对20.1 ± 9.8分钟)、失血量(29.03 ± 9.78毫升对35.69 ± 10.77毫升)、造影剂用量(288.71 ± 72.70毫升对352.78 ± 81.02毫升)和术后即刻内漏(1/34对7/41)方面表现出显著更好的结果(P < 0.05)。中风发生率(1/34对2/41)和围手术期死亡率(0/34对1/4)相似(P > 0.05)。住院时间相当(15.71 ± 6.04天对14.22 ± 5.01天,P = 0.28)。然而,Castor组的医疗耗材成本(154,168.62 ± 28,288.44元对119,589.72 ± 34,199.67元)和总住院费用(192,665.88 ± 40,027.99元对153,920.47 ± 42,670.87元)显著更高(P < 0.05)。中位随访时间为9个月(1 - 60个月)。随访显示术后30天死亡率相似(1/41对0/34,P = 1.00);支架通畅率相似(33/34对39/41,P = 0.67),支架移位率相似(0/ vs 1/41,P = 1.00)。然而,原位开窗术组的内漏率显著更高(11/41对1/34,P = 0.01)。Castor单分支支架移植物和原位开窗术技术均能有效保护和重建累及LSA的Stanford B型主动脉夹层中的LSA,Castor单分支支架移植物显示出更高的技术成功率和更少的并发症,具有更好的临床潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d868/11596501/d040e1c5053f/medi-103-e40623-g001.jpg

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