Qian Shen'er, Tan Guolin, Lei Guang, Zhang Xiaowei, Xie Zuozhong
Department of Otolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Otolaryngology Head and Neck Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China; Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Department of Otolaryngology Head and Neck Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Biochim Biophys Acta Rev Cancer. 2025 Feb;1880(1):189265. doi: 10.1016/j.bbcan.2025.189265. Epub 2025 Jan 12.
Programmed cell death is a type of autonomic and orderly cell death mode controlled by genes that maintain homeostasis and growth. Tumor is a typical manifestation of an imbalance in environmental homeostasis in the human body. Currently, several tumor treatments are designed to trigger the death of tumor cells. Nasopharyngeal carcinoma is one of the most common malignant tumors in China. It displays obvious regional and ethnic differences in its incidence, being typically high in the south and low in the north of China. Nasopharyngeal carcinoma is currently considered to be a polygenic inherited disease and is often mediated by the interaction between multiple genes or between genes and the environment. Apoptosis has long been considered the key to tumor treatment, while other cell death pathways have often been overlooked. The current study provides an overview of the relationship among apoptosis, autophagy, pyroptosis, necroptosis, ferroptosis, and nasopharyngeal carcinoma, and the regulatory pathways of nasopharyngeal carcinoma based on five cell death modes were synthesized from the view of molecule. We hope this review will help explore additional, novel programmed cell death targets for the treatment of nasopharyngeal carcinoma and thus promote in-depth research.
程序性细胞死亡是一种由基因控制的自主且有序的细胞死亡模式，可维持体内平衡和生长。肿瘤是人体环境稳态失衡的典型表现。目前，有几种肿瘤治疗方法旨在引发肿瘤细胞死亡。鼻咽癌是中国最常见的恶性肿瘤之一。其发病率存在明显的地区和种族差异，在中国通常是南方高发，北方低发。鼻咽癌目前被认为是一种多基因遗传性疾病，常由多个基因之间或基因与环境之间的相互作用介导。长期以来，细胞凋亡一直被认为是肿瘤治疗的关键，而其他细胞死亡途径常常被忽视。本研究综述了细胞凋亡、自噬、焦亡、坏死性凋亡、铁死亡与鼻咽癌之间的关系，并从分子层面综合了基于五种细胞死亡模式的鼻咽癌调控途径。我们希望这篇综述将有助于探索治疗鼻咽癌的其他新型程序性细胞死亡靶点，从而推动深入研究。
