Wei Shuxin, Han Chuangye, Mo Shutian, Huang Hailian, Luo Xiaoling
School of Basic Medical Sciences, Guangxi Medical University, Nanning, 530021, China.
Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Ministry of Education, Guangxi Medical University, Nanning, 530021, China.
Apoptosis. 2025 Feb;30(1-2):401-421. doi: 10.1007/s10495-024-02038-0. Epub 2024 Nov 2.
Cell death is a normal physiological process within cells that involves multiple pathways, such as normal DNA damage, cell cycle arrest, and programmed cell death (PCD). Cell death has been a hot spot of research in tumor-related fields, especially programmed cell death, which is a key form of cell death and is classified into different types according to the mechanism of occurrence, such as apoptosis, autophagy, necroptosis, pyroptosis, ferroptosis, and disulfidptosis. Given the important role of PCD in maintaining tissue homeostasis and inhibiting tumorigenesis and development, more and more basic and clinical studies are devoted to revealing its potential application in anti-tumor strategies. The purpose of this review is to systematically review the regulatory mechanisms of PCD and to summarize the latest research progress of anti-tumor treatment strategies based on PCD.
细胞死亡是细胞内的一种正常生理过程，涉及多种途径，如正常的DNA损伤、细胞周期停滞和程序性细胞死亡（PCD）。细胞死亡一直是肿瘤相关领域的研究热点，尤其是程序性细胞死亡，它是细胞死亡的一种关键形式，并根据发生机制分为不同类型，如凋亡、自噬、坏死性凋亡、焦亡、铁死亡和二硫键介导的细胞死亡。鉴于程序性细胞死亡在维持组织稳态以及抑制肿瘤发生和发展中的重要作用，越来越多的基础和临床研究致力于揭示其在抗肿瘤策略中的潜在应用。本综述的目的是系统地综述程序性细胞死亡的调控机制，并总结基于程序性细胞死亡的抗肿瘤治疗策略的最新研究进展。
