Manna Pulak R, Yang Shengping, Reddy P Hemachandra
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
Department of Biostatistics, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.
Biochim Biophys Acta Mol Basis Dis. 2025 Mar;1871(3):167667. doi: 10.1016/j.bbadis.2025.167667. Epub 2025 Jan 12.
Alzheimer's disease (AD)-related dementia preferentially impacts two-thirds of women and one-third of men. The steroidogenic acute regulatory (StAR) protein mediates the biosynthesis of neurosteroids that sustain diverse neuronal activities. Aging, involving neurosteroidal imbalance, is the predominant risk factor for AD causing dementia. Transcriptomic analysis, including clinical cognitive diagnosis (cogdx) stages, displays marked attenuation of StAR in brains of AD women than those of AD men, compared with cognitively normal (Non-AD) subjects. The present data provide the first evidence and new insights into the mechanism exemplifying the suppression of StAR in gender-specific differences in AD.
阿尔茨海默病（AD）相关痴呆症对三分之二的女性和三分之一的男性影响更为显著。类固醇生成急性调节（StAR）蛋白介导神经甾体的生物合成，而神经甾体维持着多种神经元活动。衰老涉及神经甾体失衡，是导致AD引发痴呆症的主要风险因素。转录组分析，包括临床认知诊断（cogdx）阶段，显示与认知正常（非AD）受试者相比，AD女性大脑中StAR的衰减程度明显高于AD男性。目前的数据提供了首个证据，并对AD性别特异性差异中StAR受抑制的机制有了新的见解。
