Skapino Estela, Gonzalez-Gayan Laura, Seral-Cortes Miguel, Sabroso-Lasa Sergio, Llorente-Cereza Ma Teresa, Leis Rosaura, Aguilera Concepción M, Gil-Campos Mercedes, Moreno Luis A, Bueno-Lozano Gloria
Nutrition School, University of La República, 11800, Montevideo, Uruguay; Growth, Exercise, Nutrition and Development (GENUD) Research Group, Department of Physiatry and Nursing, University of Zaragoza, 50009, Zaragoza, Spain.
Pediatric Endocrinology Unit, Lozano Blesa Clinic Hospital, Faculty of Medicine, University of Zaragoza, 50009, Zaragoza, Spain.
Nutr Metab Cardiovasc Dis. 2025 Apr;35(4):103811. doi: 10.1016/j.numecd.2024.103811. Epub 2024 Nov 30.
To assess the relationship between body composition indicators and inflammatory biomarkers in children and adolescents of the GENOBOX study.
Anthropometry data from 264 subjects from the subsample of Zaragoza (Spain) included: weight, height, waist circumference, body mass index and triponderal index. Body composition was determined by Dual-energy X-ray Absorptiometry (DXA), obtaining visceral adipose tissue, fat mass index and lean mass index. Age and sex specific z-scores were computed. Simple linear regression models were performed with inflammatory biomarkers (hsCRP, IL8, TNF-α, adiponectin, leptin and resistin) as dependent variables, and each of the body composition indices as independent variables. Prepubertal boys had higher IL8 and resistin values and pubertal girls had higher HOMA-IR and leptin values. hsCPR and leptin were associated with fat mass, both in prepubertals and pubertals, independently of lean mass, and regardless of how body composition was measured. All body composition indices were inversely associated with adiponectin, except for fat mass index in pubertals, but none of them were statistically significant.
A positive association between hsCRP and leptin with all body fat composition parameters, measured by standard nutritional indicators and DXA, was observed in both sexual stages.
评估GENOBOX研究中儿童和青少年身体成分指标与炎症生物标志物之间的关系。
来自西班牙萨拉戈萨子样本的264名受试者的人体测量数据包括：体重、身高、腰围、体重指数和三头肌皮褶厚度指数。通过双能X线吸收法（DXA）测定身体成分，得出内脏脂肪组织、脂肪量指数和瘦体量指数。计算年龄和性别特异性z评分。以炎症生物标志物（hsCRP、IL8、TNF-α、脂联素、瘦素和抵抗素）为因变量，以每个身体成分指数为自变量，进行简单线性回归模型分析。青春期前男孩的IL8和抵抗素值较高，青春期女孩的HOMA-IR和瘦素值较高。hsCPR和瘦素与脂肪量相关，在青春期前和青春期人群中均如此，与瘦体量无关，且与身体成分的测量方式无关。所有身体成分指数均与脂联素呈负相关，青春期人群的脂肪量指数除外，但均无统计学意义。
在两个性发育阶段，均观察到hsCRP和瘦素与通过标准营养指标和DXA测量的所有身体脂肪成分参数之间存在正相关。
