Yang Xiaolong, Lan Qiuqiu, Wang Qingan, Xue Yixuan, Zhang Jiaxing, Li Xiaoxia, Zhao Yi, Zhang Yuhong
School of Public Health, Ningxia Medical University, Yinchuan, 75004, China.
Key Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University, Yinchuan, 75004, China.
Sci Rep. 2025 Jan 14;15(1):1914. doi: 10.1038/s41598-025-85812-7.
The aim of this study was to examine the association between homocysteine (Hcy), uric acid (UA) and type 2 diabetes mellitus (T2DM), and to explore whether there was an interaction between Hcy and UA in the development of T2DM. A total of 1250 diabetic patients and 1250 non-diabetic controls were included in this case-control study. Binary logistic regression and interaction analysis were used to evaluate the association between Hcy, UA, and T2DM, and the combined effects of Hcy and UA on T2DM, respectively. Plasma Hcy and UA levels were significantly higher in diabetic patients compared to non-diabetic controls (p < 0.001, p = 0.002). Elevated Hcy and UA were risk factors for T2DM. Binary logistic regression analysis showed that compared with the lowest quartile of Hcy and UA, the highest quartile had a significantly increased risk of T2DM (OR = 1.629, 95% CI: 1.303, 2.035 for Hcy; OR = 1.596, 95% CI: 1.277, 1.995 for UA). Stratified analysis suggested a significant association between Hcy and T2DM for those aged < 65 years and males. A significant association between UA and T2DM was found in those aged ≥ 65 years, males, and BMI ≥ 24 kg/m. No significant interaction was observed between Hcy and UA (p > 0.05). Hcy and UA were risk factors for T2DM. However, there was no interaction between Hcy and UA in the risk of T2DM.
本研究旨在探讨同型半胱氨酸（Hcy）、尿酸（UA）与2型糖尿病（T2DM）之间的关联，并探究Hcy与UA在T2DM发生发展过程中是否存在相互作用。本病例对照研究共纳入1250例糖尿病患者和1250例非糖尿病对照。分别采用二元logistic回归和交互作用分析来评估Hcy、UA与T2DM之间的关联，以及Hcy和UA对T2DM的联合作用。与非糖尿病对照相比，糖尿病患者的血浆Hcy和UA水平显著更高（p < 0.001，p = 0.002）。Hcy和UA升高是T2DM的危险因素。二元logistic回归分析显示，与Hcy和UA最低四分位数相比，最高四分位数的T2DM风险显著增加（Hcy的OR = 1.629，95%CI：1.303，2.035；UA的OR = 1.596，95%CI：1.277，1.995）。分层分析表明，年龄<65岁的人群和男性中，Hcy与T2DM之间存在显著关联。在年龄≥65岁的人群、男性以及BMI≥24 kg/m²的人群中，发现UA与T2DM之间存在显著关联。未观察到Hcy与UA之间存在显著交互作用（p > 0.05）。Hcy和UA是T2DM的危险因素。然而，Hcy与UA在T2DM风险方面不存在交互作用。
