Association of homocysteine and uric acid with type 2 diabetes mellitus: a case-control study.

The aim of this study was to examine the association between homocysteine (Hcy), uric acid (UA) and type 2 diabetes mellitus (T2DM), and to explore whether there was an interaction between Hcy and UA in the development of T2DM. A total of 1250 diabetic patients and 1250 non-diabetic controls were included in this case-control study. Binary logistic regression and interaction analysis were used to evaluate the association between Hcy, UA, and T2DM, and the combined effects of Hcy and UA on T2DM, respectively. Plasma Hcy and UA levels were significantly higher in diabetic patients compared to non-diabetic controls (p < 0.001, p = 0.002). Elevated Hcy and UA were risk factors for T2DM. Binary logistic regression analysis showed that compared with the lowest quartile of Hcy and UA, the highest quartile had a significantly increased risk of T2DM (OR = 1.629, 95% CI: 1.303, 2.035 for Hcy; OR = 1.596, 95% CI: 1.277, 1.995 for UA). Stratified analysis suggested a significant association between Hcy and T2DM for those aged < 65 years and males. A significant association between UA and T2DM was found in those aged ≥ 65 years, males, and BMI ≥ 24 kg/m. No significant interaction was observed between Hcy and UA (p > 0.05). Hcy and UA were risk factors for T2DM. However, there was no interaction between Hcy and UA in the risk of T2DM.