Jung Kyoung In, Kim Yong Chan, Shin Hee Jong, Park Chan Kee
Department of Ophthalmology, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-ku, Seoul, 06591, Korea.
Seoul St. Mary's Hospital, Seoul, Korea.
Sci Rep. 2025 Jan 14;15(1):1952. doi: 10.1038/s41598-025-85505-1.
This retrospective study investigated the risk of primary open-angle glaucoma (POAG) among individuals identified as glaucoma suspects and examined associated cardiovascular risk factors. We conducted a longitudinal, nationwide cohort study using data from the Korean National Health Insurance Service (KNHIS) and included 362,285 participants aged ≥ 40 years from the Korean National Health Screening Program (NHSP) without pre-existing POAG in 2009 and 2010. Of these, glaucoma suspects (n = 32,220) were defined as individuals with at least two recorded instances of the KCD code H400 for glaucoma suspect and no prior antiglaucoma medication prescriptions before health screening. The primary outcome was the diagnosis of POAG and the prescription of antiglaucoma medications. Over a 6-year follow-up, 4.92% of glaucoma suspects developed POAG. Through multivariate Cox regression analysis, glaucoma suspects with diabetes, hypertension, dyslipidemia, or coronary heart disease exhibited a greater risk of conversion to POAG than those without these comorbidities ([HR, 1.354; 95%CI, 1.201 to 1.527] for diabetes, [HR, 1.139; 95%CI, 1.019 to 1.273] for systemic hypertension, [HR, 1.128; 95%CI, 1.013 to 1.26] for dyslipidemia, [HR, 1.124, 95%CI, 1.007 to 1.254] for coronary heart disease).This nationwide study observed that among glaucoma suspects, having cardiovascular risk factors/disease was associated with higher risk of developing POAG.
这项回顾性研究调查了被确定为青光眼疑似患者的人群中原发性开角型青光眼（POAG）的风险，并检查了相关的心血管危险因素。我们利用韩国国民健康保险服务（KNHIS）的数据进行了一项全国性的纵向队列研究，纳入了2009年和2010年韩国国民健康筛查计划（NHSP）中年龄≥40岁且无既往POAG病史的362,285名参与者。其中，青光眼疑似患者（n = 32,220）被定义为至少有两次记录的KCD代码H400（青光眼疑似）且在健康筛查前无既往抗青光眼药物处方的个体。主要结局是POAG的诊断和抗青光眼药物的处方。在6年的随访中，4.92%的青光眼疑似患者发展为POAG。通过多变量Cox回归分析，患有糖尿病、高血压、血脂异常或冠心病的青光眼疑似患者比没有这些合并症的患者转化为POAG的风险更高（糖尿病的[HR, 1.354; 95%CI, 1.201至1.527]，系统性高血压的[HR, 1.139; 95%CI, 1.019至1.273]，血脂异常的[HR, 1.128; 95%CI, 1.013至1.26]，冠心病的[HR, 1.124, 95%CI, 1.007至1.254]）。这项全国性研究观察到，在青光眼疑似患者中，患有心血管危险因素/疾病与发生POAG的较高风险相关。
