Department of Ophthalmology, Institute of Vision Research, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Healthcare Big Data Based Knowledge Integration System Research Center, Yonsei University College of Medicine, Seoul, Korea.
Acta Ophthalmol. 2018 Dec;96(8):e1025-e1030. doi: 10.1111/aos.13805. Epub 2018 Jun 4.
To evaluate the risk of open-angle glaucoma among patients with diabetes.
This retrospective propensity score-matched cohort study included patients with diabetes and a matched comparison group from the Korean National Health Insurance Service National Health Screening Cohort, which includes approximately 500 000 adults aged ≥40 years. Nondiabetes group was matched to diabetes group in a 1:1 ratio using a propensity score based on age, sex, comorbidities, antihypertensive medication use and medical care visits. Each group was followed from January 1, 2004 to either the date of developing open-angle glaucoma or the date of last follow-up in 2013.
Incidence of open-angle glaucoma was 20.0/10 000 person-years in diabetes group (n = 58 358) and 17.0/10 000 person-years in nondiabetes group (n = 58 358). Age- and sex- adjusted hazard ratio (HR) was 1.19 (95% confidence interval [CI], 1.09-1.30). In the subgroup analyses, diabetes was associated with an increased risk of open-angle glaucoma in both younger and older age groups (HR = 1.20 for those aged 40-59 years and HR = 1.18 for those aged 60-79 years) and in both sexes (men, HR = 1.13; women, HR = 1.27).
Patients diagnosed with diabetes were more likely to develop open-angle glaucoma compared with patients without diabetes.
评估糖尿病患者发生开角型青光眼的风险。
本回顾性倾向评分匹配队列研究纳入了来自韩国国民健康保险服务国家健康筛查队列的糖尿病患者和匹配的对照组，该队列包含约 50 万名年龄≥40 岁的成年人。非糖尿病组与糖尿病组按照年龄、性别、合并症、抗高血压药物使用情况和医疗就诊情况进行倾向评分 1:1 匹配。两组分别从 2004 年 1 月 1 日开始随访，直至发生开角型青光眼或 2013 年最后一次随访结束。
糖尿病组（n=58358）和非糖尿病组（n=58358）的开角型青光眼发病率分别为 20.0/10000 人年和 17.0/10000 人年。年龄和性别校正后的风险比（HR）为 1.19（95%置信区间[CI]，1.09-1.30）。亚组分析显示，糖尿病与各年龄段（40-59 岁者 HR=1.20；60-79 岁者 HR=1.18）和各性别（男性 HR=1.13；女性 HR=1.27）的开角型青光眼发病风险增加相关。
与无糖尿病患者相比，诊断为糖尿病的患者更易发生开角型青光眼。
