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慢性乙型肝炎药物治疗的现状

Current status of drug therapy for chronic hepatitis B.

作者信息

Jiang Chuang, Zhang Zhi-Hong, Li Jia-Xin

机构信息

Division of Liver Surgery, Department of General Surgery and Laboratory of Liver Surgery, and State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.

Department of General Surgery, Dafang County People's Hospital, Bijie 551600, Guizhou Province, China.

出版信息

World J Gastroenterol. 2025 Jan 14;31(2):99443. doi: 10.3748/wjg.v31.i2.99443.

Abstract

In this editorial, we comment on the article by Meng . Chronic hepatitis B (CHB) is a significant global health problem, particularly in developing countries. Hepatitis B virus (HBV) infection is one of the most important risk factors for cirrhosis and hepatocellular carcinoma. Prevention and treatment of HBV are key measures to reduce complications. At present, drug therapy can effectively control virus replication and slow disease progression, but completely eliminating the virus remains a challenge. Anti-HBV treatment is a long-term process, and there are many kinds of antiviral drugs with different mechanisms of action, it is essential to evaluate the safety and efficacy of these drugs to reduce side effects and improve patients' compliance. We will summarize the current status of CHB drug treatment, hoping to provide a reference for the selection of clinical antiviral drugs.

摘要

在这篇社论中,我们对孟的文章发表评论。慢性乙型肝炎(CHB)是一个重大的全球健康问题,在发展中国家尤为如此。乙型肝炎病毒(HBV)感染是肝硬化和肝细胞癌最重要的危险因素之一。HBV的预防和治疗是减少并发症的关键措施。目前,药物治疗可以有效控制病毒复制并减缓疾病进展,但完全清除病毒仍然是一项挑战。抗HBV治疗是一个长期过程,有多种作用机制不同的抗病毒药物,评估这些药物的安全性和有效性以减少副作用并提高患者依从性至关重要。我们将总结CHB药物治疗的现状,希望为临床抗病毒药物的选择提供参考。

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