Tabaza Haya, Farha Rana Abu, Gharaibeh Lobna, Alwahsh Mohammad, Awwad Oriana
Department of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy, University of Jordan, Amman, Jordan.
Department of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Applied Science Private University, Amman, Jordan.
J Eval Clin Pract. 2025 Feb;31(1):e14308. doi: 10.1111/jep.14308.
Chronic respiratory disorders such as asthma and chronic obstructive pulmonary disease (COPD) may deteriorate into acute exacerbations requiring hospitalization. Assessing the predictors of prolonged hospital stays could help identify potential interventions to reduce the burden on patients and healthcare systems.
This study aimed to identify the risk factors attributed to prolonged hospital stays among patients admitted with acute exacerbations of chronic respiratory disorders in Jordan.
A retrospective cohort study was conducted by reviewing the demographic and clinical characteristics of hospitalized patients with asthma and COPD exacerbations between January 2017 and July 2021. The recorded variables were checked for their independence. Simple and stepwise multivariate linear regressions were then performed to identify variables associated significantly with a longer hospital length of stay (LOS).
A total of 896 cases were evaluated. The mean ± SD stay was 5.66 ± 3.40 days, whereas the median (IQR) was 5.00 (4.00) days. Variables associated significantly with prolonged LOS in the multivariate analysis were female gender (β = 0.089, p = 0.011), pulmonary hypertension (β = 0.093, p = 0.004), allergic rhinitis (β = 0.086, p = 0.007), ICU admission (β = 0.096, p = 0.003), requirement for mechanical ventilation (β = 0.102, p = 0.002), higher total number of medications (β = 0.281, p < 0.001) and the number of exacerbation-related medications (β = 0.200, p < 0.001). However, smoking (β = -0.091, p = 0.008) was significantly associated with a shorter LOS.
Gender, pulmonary hypertension, allergic rhinitis, ICU admission, mechanical ventilation, the number of medications and smoking were significantly related to LOS. These findings emphasize the importance of patients' demographics and their clinical status in determining LOS, hence providing protective interventions to shorten it.
哮喘和慢性阻塞性肺疾病（COPD）等慢性呼吸系统疾病可能恶化为需要住院治疗的急性加重期。评估延长住院时间的预测因素有助于确定潜在的干预措施，以减轻患者和医疗系统的负担。
本研究旨在确定约旦慢性呼吸系统疾病急性加重期住院患者延长住院时间的危险因素。
通过回顾2017年1月至2021年7月期间哮喘和COPD加重期住院患者的人口统计学和临床特征进行回顾性队列研究。检查记录变量的独立性。然后进行简单和逐步多元线性回归，以确定与较长住院时间（LOS）显著相关的变量。
共评估了896例病例。平均住院时间±标准差为5.66±3.40天，而中位数（四分位间距）为5.00（4.00）天。多变量分析中与延长LOS显著相关的变量为女性（β=0.089，p=0.011）、肺动脉高压（β=0.093，p=0.004）、过敏性鼻炎（β=0.086，p=0.007）、入住重症监护病房（β=0.096，p=0.003）、需要机械通气（β=0.102，p=0.002）、药物总数较多（β=0.281，p<0.001）以及与加重相关的药物数量（β=0.200，p<0.001）。然而，吸烟（β=-0.09,1，p=0.。008）与较短的LOS显著相关。
性别、肺动脉高压、过敏性鼻炎、入住重症监护病房、机械通气、药物数量和吸烟与住院时间显著相关。这些发现强调了患者人口统计学及其临床状况在确定住院时间方面的重要性，从而提供保护性干预措施以缩短住院时间。
