Hadchouel M, Prieur A M, Griscelli C
J Pediatr. 1985 Apr;106(4):561-6. doi: 10.1016/s0022-3476(85)80072-x.
Seven children with juvenile rheumatoid arthritis had a syndrome characterized by hemorrhage and neurologic, hepatic, hematologic, and metabolic manifestations. The disease did not seem to conform clearly to the characteristics of Reye syndrome or any other well-known entity. This severe complication may be induced by macrophage activation secondary to a drug or intercurrent infection. Our data suggest that a sudden fall in erythrocyte sedimentation rate or in platelet and fibrinogen levels may mark the start of this complication and may be an indication for rapid steroid therapy.
七名青少年类风湿性关节炎患儿出现了一种以出血以及神经、肝脏、血液和代谢表现为特征的综合征。该疾病似乎并不完全符合瑞氏综合征或任何其他已知疾病的特征。这种严重并发症可能由药物或并发感染继发的巨噬细胞活化所诱发。我们的数据表明，红细胞沉降率、血小板和纤维蛋白原水平的突然下降可能标志着这种并发症的开始，并且可能是快速进行类固醇治疗的指征。
