Wang Jiaping, Hu Ming, Wang Na, Huang Tingting, Wu Huiyi, Li Hua
Department of Laboratory Medicine, Donghai Hospital Affiliated to Kangda College of Nanjing Medical University, Jiangsu Lianyungang, 223000, China.
Department of Pediatrics, Donghai Hospital Affiliated to Kangda College of Nanjing Medical University, Jiangsu Lianyungang, 223000, China.
BMC Infect Dis. 2025 Jan 14;25(1):64. doi: 10.1186/s12879-025-10472-x.
To assess the value of combined Monocyte Distribution Width (MDW) and Procalcitonin (PCT) detection in diagnosing and predicting neonatal sepsis outcomes.
This retrospective study, conducted from January 2022 to December 2023.A retrospective analysis of 39 neonatal sepsis and 30 non-infectious systemic inflammatory response syndrome (SIRS) cases was conducted. MDW, PCT, and CRP levels were compared. Relationships between variables were analyzed with Pearson correlation and Cox regression models; diagnostic performance was assessed using ROC curves.
MDW, PCT, and CRP were significantly elevated in sepsis cases (p < 0.001). In non-survivors, MDW was higher and correlated with CRP, PCT, and SNAP scores. MDW was identified as an independent predictor of 28-day mortality. Optimal MDW, PCT, and CRP cut-offs (21.3, 1.23 ng/ml, 32.8 mg/L) achieved AUCs of 0.80, 0.84, and 0.60, respectively. Combined MDW/PCT detection achieved an AUC of 0.90 with 88.2% sensitivity and 88.7% specificity.
MDW, especially when combined with PCT, improves diagnostic accuracy for neonatal sepsis management.
评估单核细胞分布宽度（MDW）与降钙素原（PCT）联合检测在诊断和预测新生儿败血症预后中的价值。
本回顾性研究于2022年1月至2023年12月进行。对39例新生儿败血症和30例非感染性全身炎症反应综合征（SIRS）病例进行回顾性分析。比较MDW、PCT和CRP水平。使用Pearson相关性分析和Cox回归模型分析变量之间的关系；使用ROC曲线评估诊断性能。
败血症病例中MDW、PCT和CRP显著升高（p < 0.001）。在非存活者中，MDW较高，且与CRP、PCT和SNAP评分相关。MDW被确定为28天死亡率的独立预测因子。最佳MDW、PCT和CRP临界值（21.3、1.23 ng/ml、32.8 mg/L）的AUC分别为0.80、0.84和0.60。MDW/PCT联合检测的AUC为0.90, 敏感性为88.2%，特异性为88.7%。
MDW，尤其是与PCT联合使用时，可提高新生儿败血症管理的诊断准确性。
