Fajar Jonny K, Tamara Fredo, Putranto Wachid, Prabowo Nurhasan A, Harapan Harapan
Department of Internal Medicine, Rumah Sakit Universitas Brawijaya, Malang, Indonesia.
Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia.
Narra J. 2024 Dec;4(3):e727. doi: 10.52225/narra.v4i3.727. Epub 2024 Dec 21.
The insertion or deletion polymorphisms of the () have been the subject of significant research related to coronavirus disease 2019 (COVID-19). Despite this, the findings have remained uncertain and debatable. The aim of this study was to determine the associations between the polymorphisms and the susceptibility as well as the severity of COVID-19. A meta-analysis study (PROSPERO: CRD42022384562) was conducted by searching the articles published on PubMed, Scopus, and Embase as of May 15, 2023. Information regarding the impact of variant on the susceptibility to COVID-19 and its severity was collected and analyzed utilizing the Mantel-Haenszel method with a random effects model or fixed effects model, depending on the presence or absence of heterogeneity. Out of 3,335 articles, 21 articles were included, of which 13 investigated the association between and the risk of COVID-19 infection and 18 of them examined its influence on disease severity. The D allele of increased risk of COVID-19 infection (OR: 1.41; 95%CI: 1.08-1.85; -Egger: 0.0676; -Heterogeneity: <0.001; =0.0120), while I allele (OR: 0.71; 95%CI: 0.54-0.93; -Egger: 0.0676; -Heterogeneity: <0.001; =0.012) and II genotype (OR: 0.55; 95%CI: 0.34-0.87; -Egger: 0.200; -Heterogeneity: <0.001; =0.011) decreased the risk of infection. Additionally, there was a notable association between the genotype and an elevated likelihood of experiencing severe COVID-19 within the Asian population (OR: 1.46; 95%CI: 1.15-1.84; -Egger: 0.092; -Heterogeneity: 0.116; =0.002). The presence of polymorphisms significantly influences the likelihood of being susceptible to and experiencing the severity of COVID-19.
（）的插入或缺失多态性一直是与2019冠状病毒病（COVID-19）相关的重要研究课题。尽管如此，研究结果仍不确定且存在争议。本研究的目的是确定（）多态性与COVID-19易感性以及严重程度之间的关联。通过检索截至2023年5月15日在PubMed、Scopus和Embase上发表的文章进行了一项荟萃分析研究（PROSPERO：CRD42022384562）。根据异质性的有无，采用随机效应模型或固定效应模型的Mantel-Haenszel方法收集并分析了有关（）变体对COVID-19易感性及其严重程度影响的信息。在3335篇文章中，纳入了21篇文章，其中13篇研究了（）与COVID-19感染风险之间的关联，其中18篇研究了其对疾病严重程度的影响。（）的D等位基因增加了COVID-19感染风险（OR：1.41；95%CI：1.08-1.85；-Egger：0.0676；-异质性：<0.001；=0.0120），而（）的I等位基因（OR：0.71；95%CI：0.54-0.93；-Egger：0.0676；-异质性：<0.001；=0.012）和II基因型（OR：0.55；95%CI：0.34-0.87；-Egger：0.200；-异质性：<0.001；=0.011）降低了感染风险。此外，在亚洲人群中，（）基因型与经历严重COVID-19的可能性增加之间存在显著关联（OR：1.46；95%CI：1.15-1.84；-Egger：0.092；-异质性：0.116；=0.002）。（）多态性的存在显著影响易患COVID-19及其严重程度的可能性。
