Liu Yanlin, Guo Ying, Zhou Huixin, Liu Yuxin, Jin Yuting, Luo Kaitao, Dou Xiaobing
College of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.
Department of Acupuncture and moxibustion, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing, Zhejiang 314033, China.
Curr Neuropharmacol. 2025;23(8):918-928. doi: 10.2174/011570159X343096241209040135.
The increasing prevalence of brain injuries resulting in cognitive and motor function impairments poses a substantial global medical challenge. Nerve repair therapies offer promise for addressing brain injury-related disorders. Ferroptosis, as a cell death mechanism associated with oxidative stress and inflammation. Certain ferroptosis inhibitors, such as iron chelators and antioxidants, exhibit therapeutic potential for brain injury-related conditions. This review explores the fundamental processes and associated mechanisms that regulate neural repair by inhibiting ferroptosis, thereby alleviating brain injury and promoting neuroregeneration. Furthermore, it examines the action mechanisms and potential therapeutic applications of ferroptosis inhibitors in neural repair, aiming to provide novel insights for treating brain injuries.
导致认知和运动功能障碍的脑损伤患病率不断上升，这给全球带来了重大的医学挑战。神经修复疗法为解决与脑损伤相关的疾病带来了希望。铁死亡是一种与氧化应激和炎症相关的细胞死亡机制。某些铁死亡抑制剂，如铁螯合剂和抗氧化剂，对与脑损伤相关的病症具有治疗潜力。本综述探讨了通过抑制铁死亡来调节神经修复的基本过程和相关机制，从而减轻脑损伤并促进神经再生。此外，还研究了铁死亡抑制剂在神经修复中的作用机制和潜在治疗应用，旨在为治疗脑损伤提供新的见解。
