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ABCA5 lipid transporter is associated with a reduced risk of Parkinson's disease.

作者信息

Galper Jasmin, Dzamko Nicolas, Kim Woojin Scott

机构信息

Brain and Mind Center & School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.

出版信息

Neural Regen Res. 2026 Feb 1;21(2):669-670. doi: 10.4103/NRR.NRR-D-24-01031. Epub 2025 Jan 13.

DOI:10.4103/NRR.NRR-D-24-01031
PMID:39819976
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12220697/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3adf/12220697/6634a46daa2f/NRR-21-669-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3adf/12220697/6634a46daa2f/NRR-21-669-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3adf/12220697/6634a46daa2f/NRR-21-669-g001.jpg

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本文引用的文献

1
A protective role of ABCA5 in response to elevated sphingomyelin levels in Parkinson's disease.ABCA5在帕金森病中对鞘磷脂水平升高的反应中的保护作用。
NPJ Parkinsons Dis. 2024 Jan 11;10(1):20. doi: 10.1038/s41531-024-00632-2.
2
ATP-binding cassette transporters as possible targets for the intervention of neurodegenerative diseases.ATP结合盒转运蛋白作为神经退行性疾病干预的潜在靶点。
Neural Regen Res. 2024 Apr;19(4):721-722. doi: 10.4103/1673-5374.382239.
3
ATP-binding cassette transporter expression is widely dysregulated in frontotemporal dementia with TDP-43 inclusions.
在伴有TDP-43包涵体的额颞叶痴呆中,ATP结合盒转运体的表达广泛失调。
Front Mol Neurosci. 2022 Nov 1;15:1043127. doi: 10.3389/fnmol.2022.1043127. eCollection 2022.
4
Strategies to gain novel Alzheimer's disease diagnostics and therapeutics using modulators of ABCA transporters.利用ABCA转运蛋白调节剂获取新型阿尔茨海默病诊断方法和治疗手段的策略。
Free Neuropathol. 2021;2:33. doi: 10.17879/freeneuropathology-2021-3528. Epub 2021 Dec 13.
5
ATP-binding cassette transporters and neurodegenerative diseases.ATP 结合盒转运蛋白与神经退行性疾病。
Essays Biochem. 2021 Dec 22;65(7):1013-1024. doi: 10.1042/EBC20210012.
6
The Role of Lipids in Parkinson's Disease.脂质在帕金森病中的作用。
Cells. 2019 Jan 7;8(1):27. doi: 10.3390/cells8010027.
7
Lysosomal storage disorders affecting the heart: a review.溶酶体贮积症心脏受累:综述。
Cardiovasc Pathol. 2019 Mar-Apr;39:12-24. doi: 10.1016/j.carpath.2018.11.002. Epub 2018 Dec 1.
8
ABCA7 Mediates Phagocytic Clearance of Amyloid-β in the Brain.ABCA7介导大脑中β淀粉样蛋白的吞噬清除。
J Alzheimers Dis. 2016 Sep 6;54(2):569-84. doi: 10.3233/JAD-160456.
9
ABCA5 regulates amyloid-β peptide production and is associated with Alzheimer's disease neuropathology.ABCA5调节β淀粉样肽的产生,并与阿尔茨海默病神经病理学相关。
J Alzheimers Dis. 2015;43(3):857-69. doi: 10.3233/JAD-141320.
10
Changes in sphingomyelin level affect alpha-synuclein and ABCA5 expression.鞘磷脂水平的变化会影响α-突触核蛋白和 ABCA5 的表达。
J Parkinsons Dis. 2012;2(1):41-6. doi: 10.3233/JPD-2012-11059.