Bétend B, Touraine J L, Hermier M, François R
Arch Fr Pediatr. 1979 Dec;36(10):995-1005.
A male infant with severe combined immunodeficiency but normal adenosine deaminase activity for whom no suitable bone marrow donor was available was given two separate grafts of both hepatic and thymic cells, the cells for each graft being taken from the same fetus aged 13 and 10 weeks respectively. Cell mediated and partial humoral immunity was restored 330 and 400 days respectively after the second transplant. No graft-versus-host reaction was observed and both red blood cell and lymphoid chimaerism could be demonstrated. The child was kept in strict bacterial isolation from the 3rd to the 537th day of life. Thirty months after the graft, the infant is in good health but has a defect of neutrophil chemotaxis and phagocytosis which requires prophylactic benzathine penicillin in addition to gammaglobulins. Fetal tissue transplantation may provide an alternative treatment for patients with severe combined immunodeficiency who do not have a histocompatible donor.
一名患有严重联合免疫缺陷但腺苷脱氨酶活性正常且无合适骨髓供体的男婴，接受了两次分别来自肝脏和胸腺细胞的移植，每次移植的细胞分别取自两个不同的胎儿，胎龄分别为13周和10周。第二次移植后分别在330天和400天恢复了细胞介导免疫和部分体液免疫。未观察到移植物抗宿主反应，且证实存在红细胞和淋巴细胞嵌合体。该患儿在出生后第3天至第537天期间处于严格的细菌隔离状态。移植30个月后，婴儿健康状况良好，但存在中性粒细胞趋化性和吞噬作用缺陷，除了使用丙种球蛋白外，还需要预防性使用苄星青霉素。对于没有组织相容性供体的严重联合免疫缺陷患者，胎儿组织移植可能提供一种替代治疗方法。
