Zhang Jie, Ye Jing, Gao Hongyuan, Mao Xiaoyan, Wu Ling
Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Rd, Shanghai, 200011, China.
J Assist Reprod Genet. 2025 Feb;42(2):589-598. doi: 10.1007/s10815-025-03390-z. Epub 2025 Jan 17.
To investigate the impact of first-trimester COVID-19 infection on the perinatal and obstetric outcomes following in vitro fertilization-frozen embryo transfer.
This retrospective study was conducted at a university-affiliated IVF center. The infection group included women who contracted SARS-CoV-2 during the first trimester following frozen embryo transfer in China's initial pandemic wave that occurred from 7 December 2022 to 7 January 2023. The control group consisted of pregnant women from the pre-pandemic period, considering the widespread incidence of the disease among the Chinese population during such a large outbreak. The primary outcome was perinatal and obstetric parameters.
A total of 346 pregnant women who tested positive for COVID-19 during the first trimester were included in the analysis, while the control group comprised 705 uninfected women (pre-COVID-19 controls). Perinatal outcomes, such as preterm birth, low birthweight, birthweight Z scores, macrosomia, small for gestational age, large for gestational age, and congenital malformations, showed no significant differences between the infected and control groups in both the unadjusted and confounder-adjusted logistic regression models. Additionally, there were no significant differences between the groups concerning obstetric complications, including gestational diabetes mellitus, hypertensive disorders of pregnancy, placenta previa, preterm premature rupture of the membrane, and mode of delivery.
The current study demonstrated that contracting COVID-19 during the first trimester did not adversely impact future obstetric and perinatal outcomes following in vitro fertilization-frozen embryo transfer. This data holds practical significance and offers essential insights for reproductive specialists and obstetricians advising expectant mothers.
探讨孕早期新型冠状病毒肺炎（COVID-19）感染对体外受精-冷冻胚胎移植术后围产期及产科结局的影响。
本回顾性研究在一所大学附属的体外受精中心进行。感染组包括在2022年12月7日至2023年1月7日中国第一波疫情期间，冷冻胚胎移植后孕早期感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的女性。考虑到在如此大规模疫情期间该疾病在中国人群中的广泛发病率，对照组由疫情前时期的孕妇组成。主要结局为围产期及产科参数。
共有346名在孕早期COVID-19检测呈阳性的孕妇纳入分析，而对照组包括705名未感染女性（COVID-19疫情前对照组）。在未调整和混杂因素调整的逻辑回归模型中，感染组和对照组在早产、低出生体重、出生体重Z评分、巨大儿、小于胎龄儿、大于胎龄儿和先天性畸形等围产期结局方面均无显著差异。此外，两组在产科并发症方面也无显著差异，包括妊娠期糖尿病、妊娠期高血压疾病、前置胎盘、胎膜早破和分娩方式。
本研究表明，孕早期感染COVID-19对体外受精-冷冻胚胎移植术后未来的产科和围产期结局没有不利影响。该数据具有实际意义，为生殖专家和为孕妇提供建议的产科医生提供了重要见解。
