Neutrophil-to-Lymphocyte Ratio (NLR) and Mean Platelet Volume (MPV) to Platelet Count Ratio in the Prognosis of Neonatal and Pediatric Sepsis.

OBJECTIVES

To calculate and assess the role of neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume (MPV)/ platelet count (PLT) ratios and their trends as prognostic indicators in neonates and children with sepsis.

METHODS

This prospective observational study was planned over a period of two years at a tertiary care teaching hospital. Two hundred seventy children with clinical suspicion of or diagnosed as sepsis were enrolled. Serial hemograms (day 1, 4, 7, 10) and trends of NLR and MPV/PLT ratios were reviewed.

RESULTS

NLR on day 10 of hospital stay had maximum sensitivity of 65% and specificity of 62%. Day 1 MPV was significantly higher in the mortality group. There was a significant correlation between lower Pediatric Sequential Organ Failure Assessment (p-SOFA) score and MPV in the survival group. MPV/PLT ratio on day 7 had maximum sensitivity of 85% and specificity of 74% in prediction of mortality. Serial decreasing trend of NLR (2.88-1.16) and MPV/PLT from day 1 to 10 (8.58-8.48) were associated with improved outcome (p < 0.001).

CONCLUSIONS

High NLR, MPV and MPV/PLT on admission are associated with increased mortality in neonatal and pediatric sepsis. Serial decreasing trends in NLR, MPV and MPV/PLT ratio are associated with improved prognosis.