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Disparities in Alcohol-Associated Liver Disease Hospital Encounters Amongst a Texas-Based Cohort of Patients.

作者信息

Cotter Thomas G, Anouti Ahmad, Zhang Bill, Rady Elias D, Patel Mausam, Patel Suraj, Ellis Daniel J, Lieber Sarah R, Rich Nicole E, O'Leary Jacqueline G, Mitchell Mack C, Singal Amit G

机构信息

Division of Digestive and Liver Diseases, UT Southwestern Medical Center, Dallas, Texas, USA.

Department of Internal Medicine, UT Southwestern Medical Centre, Dallas, Texas, USA.

出版信息

Aliment Pharmacol Ther. 2025 Mar;61(6):988-999. doi: 10.1111/apt.18477. Epub 2025 Jan 16.


DOI:10.1111/apt.18477
PMID:39821471
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11869159/
Abstract

INTRODUCTION: Alcohol-associated liver disease (ALD) disproportionately impacts men, racial and ethnic minorities, and individuals of low socioeconomic status; however, it's unclear how recent increases in ALD burden have impacted these disparities. We aimed to describe trends in racial, ethnic and socioeconomic disparities in alcohol-associated hospital encounters. METHODS: We conducted a retrospective cohort study of adult hospital encounters with alcohol-associated diagnoses from three health systems between January 2016 and December 2021. The cohort was divided into three eras: a 'Historical Era,' (Oct 2016-June 2018, used only for trends); 'Era 1' (July 2018-March 2020); and 'Era 2' (April 2020-December 2021). Kaplan Meier and Cox regression analyses were performed to identify factors associated with overall survival. RESULTS: We identified 19,295 individuals with alcohol-associated encounters (44.7% White, 29.8% Hispanic, and 21.8% non-Hispanic Black (NHB) individuals), with a greater increase observed between eras 1 and 2 than the historical era and Era 1 (8.7% vs. 5.0%, p < 0.01). By age and sex, the greatest increases in encounters were observed in the youngest and oldest females but only the oldest males. By race and ethnicity, Hispanic individuals had greater increases in encounters compared to Black and White individuals (14.8% vs. 7.5% and 6.3%, p < 0.01). Older age (aSHR: 1.03, 95% CI: 1.03-1.0), higher MELD (aSHR: 1.08, 95% CI: 1.0-1.09), hepatic encephalopathy (aSHR: 1.42, 95% CI: 1.06-1.90), and hepatocellular carcinoma (HCC) (aSHR: 3.20, 95% CI: 2.29-4.49) were associated with increased mortality. CONCLUSION: The highest increases of alcohol-associated encounters were observed amongst young Hispanic and NHB women, highlighting variation in trends by age, sex, race and ethnicity. These disparities merit further investigation to elucidate underlying mechanisms and develop tailored interventions to improve ALD burden and outcomes.

摘要

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引用本文的文献

[1]
Letter: Addressing the Growing Disparities in Alcohol-Associated Liver Disease-A Call for Equitable Healthcare Strategies: Authors' Reply.

Aliment Pharmacol Ther. 2025-6

本文引用的文献

[1]
Global and regional burden of alcohol-associated liver disease and alcohol use disorder in the elderly.

JHEP Rep. 2024-1-26

[2]
Racial and ethnic disparities in alcohol-associated liver disease in the United States: A systematic review and meta-analysis.

Hepatol Commun. 2024-4-1

[3]
Impact of COVID-19's Economic Burden on Alcohol-Related Problems: An Indirect Effect of Depression, Stress, and Anxiety.

Transl Issues Psychol Sci. 2023-6

[4]
Racial and ethnic disparities in monthly trends in alcohol-induced mortality among US adults from January 2018 through December 2021.

Am J Drug Alcohol Abuse. 2023-7-4

[5]
The impact of COVID-19 on alcohol sales and consumption in the United States: A retrospective, observational analysis.

Alcohol. 2023-9

[6]
Hospitalizations for alcoholic liver disease during the COVID-19 pandemic increased more for women, especially young women, compared to men.

World J Hepatol. 2023-2-27

[7]
Inequitable access to general and behavioral healthcare in the US during the COVID-19 pandemic: A role for telehealth?

Prev Med. 2023-4

[8]
The Changing Epidemiology of Alcohol-Associated Liver Disease: Gender, Race, and Risk Factors.

Semin Liver Dis. 2023-2

[9]
Race and Ethnicity in Non-Alcoholic Fatty Liver Disease (NAFLD): A Narrative Review.

Nutrients. 2022-10-28

[10]
Mortality in patients with end-stage liver disease above model for end-stage liver disease 3.0 of 40.

Hepatology. 2023-3-1

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