Khalil Zeyad Hossam Atta, Osman Taha Ali
College of Medicine/Radiology Department, October 6, University, 217G Pyramid Gardens, Cairo, Egypt.
Skeletal Radiol. 2025 Jan 17. doi: 10.1007/s00256-025-04872-y.
This case report describes a 15-year-old male with multifocal osteochondromatous proliferation and paraneoplastic hematologic dyscrasia, linked to latent Epstein-Barr virus reactivation. Radiographic and advanced imaging revealed widespread skeletal lesions consistent with osteochondromatosis. Hematologic evaluation indicated pancytopenia with dysplastic megakaryocytes and marrow infiltration. Immunohistochemical staining confirmed latent Epstein-Barr virus infection, suggesting its role in the pathogenesis of both the osteochondromatous and hematologic abnormalities. This case highlights the correlation between Epstein-Barr virus reactivation, bone proliferation, and paraneoplastic hematologic processes, which we believe has not yet been reported in the literature, emphasizing the need for a comprehensive diagnostic approach.
本病例报告描述了一名15岁男性，患有多灶性骨软骨瘤样增生和副肿瘤性血液系统发育异常，与潜伏性EB病毒再激活有关。影像学和高级成像显示广泛的骨骼病变，符合骨软骨瘤病。血液学评估表明全血细胞减少，伴有发育异常的巨核细胞和骨髓浸润。免疫组织化学染色证实了潜伏性EB病毒感染，提示其在骨软骨瘤样和血液学异常的发病机制中的作用。本病例突出了EB病毒再激活、骨增生和副肿瘤性血液学过程之间的相关性，我们认为这在文献中尚未见报道，强调了采用全面诊断方法的必要性。
