Li Danni, Mantyh William G, Men Lu, Jain Ishika, Glittenberg Matthew, An Binchong, Zhang Lin, Li Ling
Department of Lab Medicine and Pathology University of Minnesota Minneapolis USA.
Department of Neurology University of Minnesota Minneapolis USA.
Alzheimers Dement (Amst). 2025 Jan 16;17(1):e70072. doi: 10.1002/dad2.70072. eCollection 2025 Jan-Mar.
Little is known about the factors underpinning discordant cerebrospinal fluid (CSF) amyloid beta (Aβ) versus p-tau181/Aβ or CSF Aβ versus Aβ positron emission tomography (PET).
We stratified 570 non-demented Alzheimer's Disease Neuroimaging Initiative (ADNI) participants by Aβ PET and further by CSF Aβ or p-tau181/Aβ. We used analysis of covariance testing adjusting for covariates, followed by Tukey post hoc pairwise comparisons, to compare CSF soluble triggering receptor expressed on myeloid cells-2 (sTREM2) across four participant groups: CSF+ with CSF- , CSF- with CSF+ , and concordant CSF/CSF. We also compared sTREM2 across discordant and concordant CSF/PET.
Regardless of Aβ PET status, CSF+ with CSF- had lower sTREM2 than CSF- with CSF+. CSF sTREM2 was similarly also associated with discordant CSF Aβ42 /PET.
Our study suggests the potential roles of sTREM2 in discordant CSF Aβ and p-tau181/Aβ and discordant CSF/PET. Low- and high-CSF sTREM2 may affect the accuracy of p-tau181/Aβ during the clinical work-up of AD.
17% of non-demented older adults had discordant CSF Aβ versus p-tau181/Aβ.sTREM2 differed between discordant cases of CSF Aβ versus p-tau181/Aβ.20% of non-demented older adults had discordant CSF Aβ versus Aβ PET.sTREM2 also differed between discordant cases of CSF Aβ versus Aβ PET.p-tau181/Aβ may miss 6.7% of PET+ non-demented older adults with low sTREM2.
关于导致脑脊液（CSF）淀粉样蛋白β（Aβ）与磷酸化tau181/Aβ不一致，或CSF Aβ与Aβ正电子发射断层扫描（PET）不一致的因素，我们了解甚少。
我们根据Aβ PET对570名非痴呆的阿尔茨海默病神经影像学计划（ADNI）参与者进行分层，并进一步根据CSF Aβ或磷酸化tau181/Aβ进行分层。我们使用协方差分析并对协变量进行调整，随后进行Tukey事后成对比较，以比较四个参与者组之间的脑脊液髓样细胞上表达的可溶性触发受体2（sTREM2）：CSF+与CSF-、CSF-与CSF+，以及一致的CSF/CSF。我们还比较了不一致和一致的CSF/PET之间的sTREM2。
无论Aβ PET状态如何，CSF+与CSF-相比，sTREM2水平更低。CSF sTREM2同样也与不一致的CSF Aβ42/PET相关。
我们的研究表明sTREM2在不一致的CSF Aβ和磷酸化tau181/Aβ以及不一致的CSF/PET中可能发挥的作用。CSF sTREM2水平的高低可能会影响AD临床检查中磷酸化tau181/Aβ的准确性。
17%的非痴呆老年人CSF Aβ与磷酸化tau181/Aβ不一致。CSF Aβ与磷酸化tau181/Aβ不一致的病例中sTREM2存在差异。20%的非痴呆老年人CSF Aβ与Aβ PET不一致。CSF Aβ与Aβ PET不一致的病例中sTREM2也存在差异。磷酸化tau181/Aβ可能会遗漏6.7%的PET+且sTREM2水平低的非痴呆老年人。
