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一例原发灶不明的默克尔细胞癌，其取自正常皮肤的拭子中默克尔细胞多瘤病毒DNA水平较高。

A Case of Merkel Cell Carcinoma of Unknown Primary Origin Presenting With High Merkel Cell Polyomavirus DNA Levels in Swabs Obtained From the Normal Skin.

作者信息

Kido Issei, Kadono Takao, Hashida Yumiko, Daibata Masanori, Nakai Kozo

机构信息

Dermatology, Kochi University, Nankoku, JPN.

Microbiology and Infection, Kochi University, Nankoku, JPN.

出版信息

Cureus. 2024 Dec 16;16(12):e75837. doi: 10.7759/cureus.75837. eCollection 2024 Dec.

DOI:10.7759/cureus.75837
PMID:39822476
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11735602/
Abstract

Merkel cell carcinoma is a rare neuroendocrine tumor with high mortality. It is well known that clonal integration of the Merkel cell polyomavirus into the dermal precursor cells is a hypothesized pathway in Merkel cell carcinoma pathogenesis. Here, we demonstrate a case of Merkel cell carcinoma (primary origin unknown) presenting with high Merkel cell polyomavirus DNA levels in swabs obtained from normal skin.

摘要

默克尔细胞癌是一种罕见的神经内分泌肿瘤，死亡率很高。众所周知，默克尔细胞多瘤病毒克隆整合到真皮前体细胞中是默克尔细胞癌发病机制中的一种假设途径。在此，我们报告一例默克尔细胞癌（原发部位不明）病例，其取自正常皮肤的拭子中默克尔细胞多瘤病毒DNA水平很高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38bf/11735602/f02ef7961512/cureus-0016-00000075837-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38bf/11735602/14949ff229ae/cureus-0016-00000075837-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38bf/11735602/3e819f2750b1/cureus-0016-00000075837-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38bf/11735602/949deb2850c8/cureus-0016-00000075837-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38bf/11735602/4b64866c2e84/cureus-0016-00000075837-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38bf/11735602/c197b1b33ff9/cureus-0016-00000075837-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38bf/11735602/f02ef7961512/cureus-0016-00000075837-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38bf/11735602/14949ff229ae/cureus-0016-00000075837-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38bf/11735602/3e819f2750b1/cureus-0016-00000075837-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38bf/11735602/949deb2850c8/cureus-0016-00000075837-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38bf/11735602/4b64866c2e84/cureus-0016-00000075837-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38bf/11735602/c197b1b33ff9/cureus-0016-00000075837-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38bf/11735602/f02ef7961512/cureus-0016-00000075837-i06.jpg

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A Case of Merkel Cell Carcinoma of Unknown Primary Origin Presenting With High Merkel Cell Polyomavirus DNA Levels in Swabs Obtained From the Normal Skin.一例原发灶不明的默克尔细胞癌，其取自正常皮肤的拭子中默克尔细胞多瘤病毒DNA水平较高。
Cureus. 2024 Dec 16;16(12):e75837. doi: 10.7759/cureus.75837. eCollection 2024 Dec.
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本文引用的文献

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Merkel cell carcinoma of unknown primary: Clinical presentation and outcomes.原发灶不明的默克尔细胞癌：临床表现与预后
J Surg Oncol. 2022 Nov;126(6):1080-1086. doi: 10.1002/jso.27010. Epub 2022 Jul 9.
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Merkel Cell Carcinoma of Unknown Primary: Immunohistochemical and Molecular Analyses Reveal Distinct UV-Signature/MCPyV-Negative and High Immunogenicity/MCPyV-Positive Profiles.原发灶不明的默克尔细胞癌：免疫组织化学和分子分析揭示不同的紫外线特征/ Merkel细胞多瘤病毒阴性及高免疫原性/ Merkel细胞多瘤病毒阳性特征
Cancers (Basel). 2021 Mar 31;13(7):1621. doi: 10.3390/cancers13071621.
3
Reviewing the current evidence supporting early B-cells as the cellular origin of Merkel cell carcinoma.
回顾目前支持早期B细胞作为默克尔细胞癌细胞起源的证据。
Crit Rev Oncol Hematol. 2017 Aug;116:99-105. doi: 10.1016/j.critrevonc.2017.05.009. Epub 2017 Jun 3.
4
High load of Merkel cell polyomavirus DNA detected in the normal skin of Japanese patients with Merkel cell carcinoma.在日本默克尔细胞癌患者的正常皮肤中检测到高负荷的默克尔细胞多瘤病毒DNA。
J Clin Virol. 2016 Sep;82:101-107. doi: 10.1016/j.jcv.2016.07.011. Epub 2016 Jul 21.
5
Analysis of Prognostic Factors from 9387 Merkel Cell Carcinoma Cases Forms the Basis for the New 8th Edition AJCC Staging System.对9387例默克尔细胞癌病例的预后因素分析构成了新版美国癌症联合委员会（AJCC）第8版分期系统的基础。
Ann Surg Oncol. 2016 Oct;23(11):3564-3571. doi: 10.1245/s10434-016-5266-4. Epub 2016 May 19.
6
Ecology of Merkel Cell Polyomavirus in Healthy Skin Among Individuals in an Asian Cohort.亚洲队列中健康个体皮肤中默克尔细胞多瘤病毒的生态学
J Infect Dis. 2016 Jun 1;213(11):1708-16. doi: 10.1093/infdis/jiw040. Epub 2016 Feb 9.
7
Merkel cell carcinoma of lymph node with unknown primary has a significantly lower association with Merkel cell polyomavirus than its cutaneous counterpart.淋巴结原发不明的 Merkel 细胞癌与 Merkel 细胞多瘤病毒的关联明显低于其皮肤型。
Mod Pathol. 2014 Sep;27(9):1182-92. doi: 10.1038/modpathol.2013.250. Epub 2014 Jan 10.
8
Merkel cell polyomavirus: a newly discovered human virus with oncogenic potential.默克尔细胞多瘤病毒：一种具有致癌潜能的新发现的人类病毒。
Virology. 2013 Jan 5;435(1):118-30. doi: 10.1016/j.virol.2012.09.029.
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Epidemiology and survival of Merkel cell carcinoma in the Netherlands. A population-based study of 808 cases in 1993-2007.荷兰 Merkel 细胞癌的流行病学和生存情况。1993-2007 年间 808 例病例的基于人群的研究。
Eur J Cancer. 2011 Mar;47(4):579-85. doi: 10.1016/j.ejca.2010.11.002. Epub 2010 Dec 6.
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The etiology and epidemiology of merkel cell carcinoma.默克尔细胞癌的病因学与流行病学
Curr Probl Cancer. 2010 Jan-Feb;34(1):14-37. doi: 10.1016/j.currproblcancer.2010.01.001.