鸡矢藤富含黄酮类化合物的提取物通过调节尿酸代谢和肠道微生物群来改善高尿酸血症。
Flavonoid-rich extract of Paederia scandens (Lour.) Merrill improves hyperuricemia by regulating uric acid metabolism and gut microbiota.
作者信息
Liu Yuyi, Sheng Shanling, Wu Linye, Wang Huixian, Xue Hui, Wang Ruimin
机构信息
Key Laboratory of Food Nutrition and Functional Food of Hainan Province, School of Food Science and Engineering, Hainan University, Haikou 570228, China.
Key Laboratory of Food Nutrition and Functional Food of Hainan Province, School of Food Science and Engineering, Hainan University, Haikou 570228, China.
出版信息
Food Chem. 2025 Apr 15;471:142857. doi: 10.1016/j.foodchem.2025.142857. Epub 2025 Jan 11.
Paederia scandens (Lour.) Merrill flavonoid-rich extract (PSMF) has shown excellent xanthine oxidase (XOD) inhibitory activity in our previous study. However, the efficacy of PSMF in mitigating hyperuricemia (HUA) remains to be elucidated. In this study, we investigated the effects and mechanisms of PSMF on alleviating in HUA mice. The results showed that PSMF intervention reduced serum levels of uric acid (UA), creatinine (CRE), and blood urea nitrogen (BUN), and inhibited the activities of XOD and adenosine deaminase (ADA). In addition, PSMF treatment not only attenuated the inflammatory response and renal damage but also regulated the expression of UA synthesis genes and UA excretion genes. Finally, PSMF ameliorated gut microbiota dysbiosis in HUA mice by enriching the abundance of short-chain fatty acid (SCFA)-producing bacteria. In summary, PSMF appears to be a promising natural source for the prevention and treatment of HUA.
鸡矢藤富含黄酮类提取物（PSMF）在我们之前的研究中已显示出优异的黄嘌呤氧化酶（XOD）抑制活性。然而，PSMF在减轻高尿酸血症（HUA）方面的功效仍有待阐明。在本研究中，我们研究了PSMF对缓解HUA小鼠的作用及其机制。结果表明，PSMF干预降低了血清尿酸（UA）、肌酐（CRE）和血尿素氮（BUN）水平，并抑制了XOD和腺苷脱氨酶（ADA）的活性。此外，PSMF治疗不仅减轻了炎症反应和肾脏损伤，还调节了UA合成基因和UA排泄基因的表达。最后，PSMF通过增加产生短链脂肪酸（SCFA）细菌的丰度改善了HUA小鼠的肠道微生物群失调。总之，PSMF似乎是预防和治疗HUA的一种有前景的天然来源。
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