Kourosh-Arami Masoumeh, Ramezani Mahdi, Komaki Alireza
Department of Physiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
J Physiol Sci. 2025 Mar;75(1):100004. doi: 10.1016/j.jphyss.2024.100004. Epub 2025 Jan 2.
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by progressive cognitive decline and memory loss. Sleep-wake disorders are an extremely predominant and often disabling aspect of AD. Ox is vital in maintaining the sleep-wake cycle and promoting wakefulness. Dysfunction of Ox signaling has been associated with sleep disorders such as narcolepsy. In AD patients, the increase in cerebrospinal fluid Ox levels is related to parallel sleep deterioration. The relationship between AD and sleep disturbances has gained increasing attention due to their potential bidirectional influence. Disruptions in sleep patterns are commonly observed in AD patients, leading researchers to investigate the possible involvement of Ox in sleep disturbances characteristic of the disease. This review article explores the role of the Ox system in AD, and the intricate relationship between AD and sleep, highlighting the potential mechanisms, impact on disease pathology, and therapeutic interventions to improve sleep quality in affected individuals.
阿尔茨海默病（AD）是一种毁灭性的神经退行性疾病，其特征为进行性认知衰退和记忆丧失。睡眠-觉醒障碍是AD极为突出且常导致功能障碍的一个方面。下丘脑泌素在维持睡眠-觉醒周期和促进觉醒方面至关重要。下丘脑泌素信号功能障碍与发作性睡病等睡眠障碍有关。在AD患者中，脑脊液中下丘脑泌素水平的升高与睡眠质量的平行恶化有关。由于AD与睡眠障碍之间可能存在双向影响，它们之间的关系已越来越受到关注。AD患者中常见睡眠模式紊乱，这促使研究人员探究下丘脑泌素在该疾病特征性睡眠障碍中可能发挥的作用。这篇综述文章探讨了下丘脑泌素系统在AD中的作用，以及AD与睡眠之间的复杂关系，强调了潜在机制、对疾病病理的影响以及改善受影响个体睡眠质量的治疗干预措施。
