Liu Jingjing, Shi Yijian, Xie Shuqi, Xing Liangyu, Wang Lu, Li Wentian, Zhao Xudong
Department of Psychosomatic Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
Department of Psychology, Shanghai Normal University, Shanghai 200234, China.
J Affect Disord. 2025 Apr 1;374:443-459. doi: 10.1016/j.jad.2025.01.067. Epub 2025 Jan 15.
Childhood trauma is an early pathogenic factor that increases individuals' vulnerability to mental illness. This systematic review aims to explore the evidence regarding the association between childhood trauma and the subsequent occurrence of anxiety disorders.
Embase, Scopus, and PubMed databases were searched for peer-reviewed longitudinal cohort studies published in English between January 1, 1995, and November 15, 2022. These studies investigated the association between childhood traumas and later diagnose of anxiety disorders. Including studies in one previous meta-analysis and two umbrella reviews, a total of 27 manuscripts were retained in this meta-analysis.
The evidence strongly revealed that childhood trauma exposure has detrimental effects on anxiety disorders, consistent from youth to adulthood. Moreover, these effects remained consistent across various types of anxiety disorders, including generalized anxiety disorder and social anxiety disorder, agoraphobia, specific phobia, panic attack and panic disorder. Importantly, exposure to childhood trauma, including maternal dysfunction, paternal dysfunction, physical abuse, sexual abuse, emotional abuse and bullying, was associated with later development of anxiety disorders, with bullying and maternal dysfunction ranking highest.
This meta-analysis underscores that childhood trauma exposure significantly increases the risk of anxiety disorders across different age groups and types of anxiety disorders. Various forms of childhood trauma, including maternal dysfunction, paternal dysfunction, physical abuse, sexual abuse, emotional abuse and bullying, are consistently associated with later development of anxiety disorders, highlighting the importance of early intervention and support in preventing anxiety disorders.
童年创伤是一种早期致病因素，会增加个体患精神疾病的易感性。本系统评价旨在探讨童年创伤与随后发生焦虑症之间关联的证据。
检索了Embase、Scopus和PubMed数据库，以查找1995年1月1日至2022年11月15日期间以英文发表的经同行评审的纵向队列研究。这些研究调查了童年创伤与后来诊断的焦虑症之间的关联。包括一项先前的荟萃分析和两项综述中的研究，本荟萃分析共保留了27篇手稿。
证据有力地表明，童年创伤暴露对焦虑症有有害影响，从青少年到成年期都是一致的。此外，这些影响在各种类型的焦虑症中都保持一致，包括广泛性焦虑症、社交焦虑症、广场恐惧症、特定恐惧症、惊恐发作和惊恐障碍。重要的是，童年创伤暴露，包括母亲功能障碍、父亲功能障碍、身体虐待、性虐待、情感虐待和欺凌，与后来焦虑症的发生有关，其中欺凌和母亲功能障碍的关联度最高。
这项荟萃分析强调，童年创伤暴露显著增加了不同年龄组和不同类型焦虑症的患病风险。各种形式的童年创伤，包括母亲功能障碍、父亲功能障碍、身体虐待、性虐待、情感虐待和欺凌，都与后来焦虑症的发生持续相关，凸显了早期干预和支持在预防焦虑症方面的重要性。
