Koneru Manisha, Lakhani Dhairya A, Xu Risheng, Salim Hamza Adel, Urrutia Victor C, Marsh Elisabeth B, Dmytriw Adam A, Guenego Adrien, Llinas Rafael H, Hillis Argye E, Nael Kambiz, Wintermark Max, Albers Gregory W, Heit Jeremy J, Faizy Tobias D, Yedavalli Vivek
Cooper University Health Care, Camden, New Jersey, USA.
West Virginia University, Morgantown, West Virginia, USA.
J Neurointerv Surg. 2025 Jan 16. doi: 10.1136/jnis-2024-022609.
The cerebral blood volume index (CBV index) is a perfusion-based marker of collateral status. Several real-world data analyses from observational stroke cohorts have established relationships between this parameter and a range of favorable and unfavorable stroke outcomes. In this review, an overview is provided of the CBV index, within the context of thrombectomy-treated large vessel and medium vessel occlusion ischemic strokes. The current literature is summarized describing the CBV index and its association with a variety of efficacy, safety, and clinical outcome measures during the thrombectomy course and post-treatment recovery in both large vessel occlusion and medium vessel occlusion strokes. The range of CBV index value thresholds that have been identified and are able to differentiate between favorable and unfavorable outcomes across different clinical scenarios are summarized. This review underscores the need for additional analyses to further explore the CBV index in other clinical outcome contexts and for future prospective studies to validate the CBV index in thrombectomy-treated large vessel and medium vessel occlusion strokes, especially with increasing use of thrombectomy for treating medium vessel occlusions.
脑血容量指数（CBV指数）是基于灌注的侧支循环状态标志物。来自观察性卒中队列的多项真实世界数据分析已经确立了该参数与一系列有利和不利卒中结局之间的关系。在本综述中，在血栓切除术治疗的大血管和中血管闭塞性缺血性卒中背景下，对CBV指数进行了概述。总结了当前文献，描述了CBV指数及其在大血管闭塞和中血管闭塞性卒中的血栓切除术过程及治疗后恢复期间与各种疗效、安全性和临床结局指标的关联。总结了已确定的、能够在不同临床场景中区分有利和不利结局的CBV指数值阈值范围。本综述强调需要进行更多分析，以在其他临床结局背景下进一步探索CBV指数，并开展未来前瞻性研究，以验证CBV指数在血栓切除术治疗的大血管和中血管闭塞性卒中中的作用，尤其是随着血栓切除术用于治疗中血管闭塞的应用日益增加。
