IRE1α-XBP1发挥兼职功能限制白血病。 - Suppr

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超能文献

IRE1α-XBP1 moonlighting to restrict leukemia.

作者信息

Xie Stephanie Z

机构信息

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

出版信息

Nat Immunol. 2025 Feb;26(2):157-158. doi: 10.1038/s41590-024-02061-y.

DOI:10.1038/s41590-024-02061-y

PMID:39825092

Abstract

摘要

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IRE1α-XBP1 moonlighting to restrict leukemia.IRE1α-XBP1发挥兼职功能限制白血病。

Nat Immunol. 2025 Feb;26(2):157-158. doi: 10.1038/s41590-024-02061-y.

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Live imaging of the co-translational recruitment of XBP1 mRNA to the ER and its processing by diffuse, non-polarized IRE1α.活细胞成像显示 XBP1 mRNA 共翻译募集到内质网并被弥散、非极化的 IRE1α 进行加工。

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本文引用的文献

IRE1α-XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs.IRE1α-XBP1通过限制促白血病基因程序来保护造血干细胞和祖细胞。

Nat Immunol. 2025 Feb;26(2):200-214. doi: 10.1038/s41590-024-02063-w. Epub 2025 Jan 9.

C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress-Induced Ferroptosis in FLT3-Mutant Leukemia.C/EBPα赋予FLT3突变型白血病对脂肪酸合成途径的依赖性以及对脂质氧化应激诱导的铁死亡的易感性。

Cancer Discov. 2023 Jul 7;13(7):1720-1747. doi: 10.1158/2159-8290.CD-22-0411.

Cancer cell-intrinsic XBP1 drives immunosuppressive reprogramming of intratumoral myeloid cells by promoting cholesterol production.癌细胞内在的XBP1通过促进胆固醇生成来驱动肿瘤内髓样细胞的免疫抑制重编程。

Cell Metab. 2022 Dec 6;34(12):2018-2035.e8. doi: 10.1016/j.cmet.2022.10.010. Epub 2022 Nov 8.

A cellular hierarchy framework for understanding heterogeneity and predicting drug response in acute myeloid leukemia.一种用于理解急性髓系白血病异质性和预测药物反应的细胞层次结构框架。

Nat Med. 2022 Jun;28(6):1212-1223. doi: 10.1038/s41591-022-01819-x. Epub 2022 May 26.

Sphingosine-1-phosphate receptor 3 potentiates inflammatory programs in normal and leukemia stem cells to promote differentiation.鞘氨醇-1-磷酸受体 3 增强正常和白血病干细胞中的炎症程序，以促进分化。

Blood Cancer Discov. 2021 Jan 1;2(1):32-53. doi: 10.1158/2643-3230.BCD-20-0155. Epub 2020 Dec 1.

Pharmacological Targeting of IRE1 in Cancer.IRE1 在癌症中的药理学靶向治疗。

Trends Cancer. 2020 Dec;6(12):1018-1030. doi: 10.1016/j.trecan.2020.07.006. Epub 2020 Aug 26.

Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity.单细胞 RNA-Seq 揭示与疾病进展和免疫相关的 AML 层次结构。

Cell. 2019 Mar 7;176(6):1265-1281.e24. doi: 10.1016/j.cell.2019.01.031. Epub 2019 Feb 28.

Adaptive endoplasmic reticulum stress signalling via IRE1α-XBP1 preserves self-renewal of haematopoietic and pre-leukaemic stem cells.IRE1α-XBP1 介导的适应性内质网应激信号转导维持造血和白血病前干细胞的自我更新。

Nat Cell Biol. 2019 Mar;21(3):328-337. doi: 10.1038/s41556-019-0285-6. Epub 2019 Feb 18.

Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia.抑制由肌醇需求酶1α（IRE1α）驱动的促生存通路在急性髓系白血病中是一种很有前景的治疗应用。

Oncotarget. 2016 Apr 5;7(14):18736-49. doi: 10.18632/oncotarget.7702.

The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress.未折叠蛋白反应在应激过程中控制造血干细胞库的完整性。

Nature. 2014 Jun 12;510(7504):268-72. doi: 10.1038/nature13228. Epub 2014 Apr 28.

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