Limon-Miro Ana Teresa, Sekulic Karolina, Isley Serena, Prado Carla M, Tandon Puneeta
Human Nutrition Research Unit, Department of Agricultural, Food, and Nutritional Science, Faculty of Agricultural, Life, & Environmental Sciences, University of Alberta, Edmonton, AB, Canada.
Division of Gastroenterology (Liver Unit), Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Eur J Clin Nutr. 2025 May;79(5):494-497. doi: 10.1038/s41430-024-01562-1. Epub 2025 Jan 17.
The accurate assessment of body composition in cirrhosis is challenging as fluid accumulation affects most techniques. The whole-body counter is a state-of-the-art method that measures total body potassium (TBK) unbiased by fluid, from which body cell mass (BCM) is derived. This pilot study in 20 patients with cirrhosis evaluated bedside tools including the liver frailty index (LFI), bioimpedance analysis-based phase angle, calf circumference (CC), and BMI (body mass index)/edema-adjusted CC, and explored their association with TBK and BCM. Stepwise multiple linear regression analysis and Pearson's correlation tests were conducted. Adjusted for sex, BCM and TBK were inversely associated with frailty (p < 0.0001). LFI r = -0.568 (p = 0.009), CC r = 0.484 (p = 0.031), and edema-adjusted CC r = 0.467 (p = 0.038), demonstrated moderate correlations with BCM. Further research involving a larger sample of participants is needed to confirm these findings associating these bedside tools and gold-standard body composition measures.
由于液体潴留会影响大多数技术，因此准确评估肝硬化患者的身体成分具有挑战性。全身计数器是一种先进的方法，可测量不受液体影响的全身钾含量（TBK），并由此得出身体细胞质量（BCM）。这项针对20例肝硬化患者的初步研究评估了包括肝脏脆弱指数（LFI）、基于生物电阻抗分析的相角、小腿围（CC）以及BMI（体重指数）/经水肿调整的CC在内的床边工具，并探讨了它们与TBK和BCM的关联。进行了逐步多元线性回归分析和Pearson相关性检验。在对性别进行校正后，BCM和TBK与身体虚弱呈负相关（p < 0.0001）。LFI的r值为-0.568（p = 0.009），CC的r值为0.484（p = 0.031），经水肿调整的CC的r值为0.467（p = 0.038），表明与BCM存在中度相关性。需要进一步开展涉及更大样本参与者的研究，以证实这些将这些床边工具与金标准身体成分测量方法相关联的发现。
